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TNF-Alpha Soluble

Published: July 27, 2026Updated: August 25, 2026

This biomarker measures the levels of soluble Tumor Necrosis Factor-Alpha (TNF-alpha), a key inflammatory cytokine, in the blood.

Quick summary

TNF-alpha soluble levels help diagnose inflammatory conditions.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
pg/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche TNF-alpha, R&D Systems TNF-alpha
interpretation: {"text":"0–2000 pg/mL: Levels within this range are generally considered normal.","label":"Normal"}; {"text":">2000 pg/mL: Levels above this range may indicate an inflammatory condition or infection.","label":"Elevated"}

TNF-alpha is a critical inflammatory cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction.

Elevated levels of TNF-alpha are associated with various inflammatory and autoimmune conditions, including rheumatoid arthritis, inflammatory bowel disease, and psoriasis.

Measuring TNF-alpha levels can aid in the diagnosis and monitoring of these conditions, as well as in assessing the effectiveness of anti-inflammatory treatments.

Frequently asked questions

What conditions are associated with high TNF-alpha levels?
High TNF-alpha levels are often associated with inflammatory conditions such as rheumatoid arthritis, Crohn's disease, and psoriasis.
How can TNF-alpha levels be reduced?
TNF-alpha levels can be reduced through medications such as TNF-alpha inhibitors, lifestyle changes, and other anti-inflammatory treatments.
  1. 1
    Tumor Necrosis Factor AlphaSource
  2. 2
    Role of TNF-alpha in InflammationSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy