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Total Protein

Published: July 27, 2026Updated: August 25, 2026

Total protein measures the combined amount of albumin and globulin in the blood, which helps assess liver and kidney function, nutritional status, and various diseases.

Quick summary

Total protein assesses liver function, nutritional status, and disease presence.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
g/dL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Total Protein, Abbott Total Protein, Siemens Total Protein
interpretation: {"text":"May indicate liver disease, malnutrition, or malabsorption disorders.","label":"Low"}; {"text":"Could suggest chronic inflammation, dehydration, or bone marrow disorders.","label":"High"}

Total protein is a blood test that quantifies the total amount of protein in the serum, which includes albumin and globulin. Albumin is essential for maintaining oncotic pressure and transporting substances in the blood, while globulins play a crucial role in the immune response and blood clotting.

The normal range for total protein is typically between 6.0 and 8.3 g/dL. Deviations from this range can indicate a variety of health issues, such as liver disease, kidney dysfunction, malnutrition, or certain cancers.

Low total protein levels may suggest liver disease, malnutrition, or malabsorption disorders, whereas high levels can be associated with chronic inflammation, dehydration, or certain bone marrow disorders.

Frequently asked questions

What does a low total protein level mean?
A low total protein level may indicate liver disease, malnutrition, or malabsorption disorders.
What does a high total protein level indicate?
A high total protein level could suggest chronic inflammation, dehydration, or bone marrow disorders.
  1. 1
    Mayo Clinic: Total Protein TestSource
  2. 2
    MedlinePlus: Total ProteinSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy