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Thyroid Peroxidase (TPO) IgG Antibody Load

Published: July 27, 2026Updated: August 25, 2026

This biomarker measures the level of IgG antibodies against thyroid peroxidase (TPO) in the blood, which is indicative of autoimmune thyroid disorders.

Quick summary

TPO IgG Antibody Load is used to diagnose autoimmune thyroid conditions.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
IU/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Anti-TPO IgG, Abbott Anti-TPO IgG
interpretation: {"text":"0–34 IU/mL: No significant evidence of autoimmune thyroid disease.","label":"Normal"}; {"text":">34 IU/mL: Increased risk of autoimmune thyroid disorders such as Hashimoto's thyroiditis or Graves' disease.","label":"Elevated"}

Thyroid peroxidase (TPO) is an enzyme crucial for the production of thyroid hormones. The presence of IgG antibodies against TPO indicates the immune system is attacking the thyroid gland.

Elevated levels of TPO IgG antibodies are commonly found in patients with Hashimoto's thyroiditis and Graves' disease, making this test essential for diagnosing autoimmune thyroid disorders.

The reference range for TPO IgG Antibody Load is 0–34 IU/mL. Values above this range suggest an increased likelihood of an autoimmune thyroid condition.

Frequently asked questions

What does a high TPO IgG antibody level mean?
A high level indicates an increased risk of autoimmune thyroid diseases like Hashimoto's thyroiditis or Graves' disease.
Can TPO IgG antibodies be treated?
While the antibodies themselves cannot be treated, the associated thyroid conditions can be managed with medication and lifestyle changes.
  1. 1
    American Thyroid AssociationSource
  2. 2
    Mayo ClinicSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy