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Transferrin Saturation

Published: July 27, 2026Updated: August 25, 2026

Transferrin saturation measures the percentage of transferrin binding sites occupied by iron in the blood, indicating iron availability and storage.

Quick summary

Transferrin saturation reflects the proportion of iron-bound transferrin in the blood.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
%
Clinical utility
diagnostic
Result kind
semi_quantitative
FDA-cleared
Roche Transferrin Saturation, Abbott Transferrin Saturation
interpretation: {"text":"Indicates potential iron deficiency or anemia. Values below 20% may require further investigation.","label":"Low"}; {"text":"Suggests iron overload or hemochromatosis. Values above 50% may warrant clinical intervention.","label":"High"}

Transferrin saturation (TSAT) is a hematological parameter that quantifies the percentage of transferrin molecules that are bound to iron. It is calculated by dividing the serum iron concentration by the total iron-binding capacity (TIBC) and multiplying by 100.

This biomarker is crucial for assessing iron status in the body, as it reflects the balance between iron supply and demand. Low TSAT levels may indicate iron deficiency, while high levels can suggest iron overload.

TSAT is commonly used in the diagnosis and monitoring of conditions such as anemia, hemochromatosis, and other disorders related to iron metabolism.

Frequently asked questions

What is a normal transferrin saturation level?
Normal transferrin saturation levels range from 20% to 50%.
What conditions can cause abnormal TSAT levels?
Low TSAT levels may result from iron deficiency, chronic blood loss, or malnutrition, while high levels can be due to hemochromatosis, liver disease, or iron supplementation.
  1. 1
    Transferrin Saturation TestSource
  2. 2
    Iron Metabolism and StorageSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy