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Urine Protein-to-Creatinine Ratio (UPCR)

Published: July 27, 2026Updated: August 25, 2026

The UPCR measures the amount of protein excreted in the urine relative to the amount of creatinine, providing an assessment of kidney function.

Quick summary

UPCR helps diagnose and monitor kidney disease by measuring protein excretion in urine.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
mg/g
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Urine Protein, Abbott Urine Protein
interpretation: {"text":"UPCR below 150 mg/g indicates normal protein excretion and suggests healthy kidney function.","label":"Normal"}; {"text":"UPCR above 150 mg/g may indicate kidney disease and warrants further evaluation.","label":"Elevated"}

The urine protein-to-creatinine ratio (UPCR) is a diagnostic test that quantifies the amount of protein in the urine compared to creatinine. This ratio is used to assess kidney damage and function, as healthy kidneys typically excrete very little protein.

A UPCR value above the reference range (0–150 mg/g) may indicate kidney disease, such as glomerulonephritis or diabetic nephropathy. It is a key marker in the early detection and management of renal disorders.

Regular monitoring of UPCR is crucial for patients with chronic kidney disease (CKD) to track disease progression and the effectiveness of treatment interventions.

Frequently asked questions

What is a normal UPCR value?
A normal UPCR is typically below 150 mg/g, indicating minimal protein excretion in the urine.
What does a high UPCR mean?
A high UPCR may suggest kidney damage or disease, such as glomerulonephritis or diabetic nephropathy, and should be discussed with a healthcare provider.
  1. 1
    Urine Protein-to-Creatinine Ratio (UPCR)Source
  2. 2
    Proteinuria: Diagnosis and ManagementSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy