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ZAAT-1 Antibody

Published: July 27, 2026Updated: August 25, 2026

The ZAAT-1 antibody test measures the levels of antibodies against alpha-1 antitrypsin (AAT) in the blood, which can indicate autoimmune responses or deficiency.

Quick summary

ZAAT-1 antibody levels help diagnose autoimmune conditions or AAT deficiency.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
FDA Cleared General Assay
interpretation: {"text":"ZAAT-1 antibody levels within the reference range (0–15 U/mL) are generally considered normal.","label":"Low Levels"}; {"text":"Levels above 15 U/mL may indicate an autoimmune response or AAT deficiency, warranting further investigation.","label":"High Levels"}

The ZAAT-1 antibody test is used to detect the presence of antibodies against alpha-1 antitrypsin (AAT), a protein that protects tissues from damage caused by inflammatory enzymes.

Elevated levels of ZAAT-1 antibodies may suggest an autoimmune response, where the body mistakenly attacks its own AAT, leading to deficiency and potential lung or liver disease.

This test is particularly useful in diagnosing conditions such as autoimmune hepatitis, certain types of vasculitis, and other inflammatory disorders.

Frequently asked questions

What conditions can elevated ZAAT-1 antibodies indicate?
Elevated levels may indicate autoimmune conditions such as autoimmune hepatitis, vasculitis, or other inflammatory disorders.
How is the ZAAT-1 antibody test performed?
The test is performed on a blood sample, typically drawn from a vein in the arm.
  1. 1
    Alpha-1 Antitrypsin Deficiency - Mayo ClinicSource
  2. 2
    Autoimmune Hepatitis - National Institute of Diabetes and Digestive and Kidney DiseasesSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy