2 8 Dihydroxyadenine Crystalluria C5676845
A condition where crystal-like deposits form in the urine due to an enzyme deficiency. Can cause kidney stones and kidney problems. Treated with medication and dietary changes.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Fever with Chills
Elevated body temperature often accompanied by shivering, which may indicate a urinary tract infection or kidney involvement.
Seek immediate medical attention as fever may indicate a serious infection requiring prompt treatment.
Acute Kidney Injury
Sudden decrease in kidney function causing waste buildup in the blood, with symptoms including decreased urine output, swelling, and confusion.
This is a medical emergency. Seek immediate care if you experience decreased urination, severe swelling, shortness of breath, or confusion.
Flank Pain
(renal)Intense pain in the side or back below the ribs, often radiating to the groin, caused by kidney stones or crystal deposits in the urinary tract.
Frequency: 70-80% of patients
Hematuria
(renal)Presence of blood in the urine, which may appear pink, red, or brown. Often visible to the naked eye (gross hematuria).
Frequency: 60-70% of patients
Nausea with Vomiting
(gastrointestinal)Feeling sick to the stomach with possible vomiting, often accompanying severe flank or abdominal pain from kidney involvement.
Frequency: 40-50% of patients
Dysuria
(renal)Painful, burning sensation during urination, often described as a sharp sting. May be accompanied by urgency or frequency.
Frequency: 35-45% of patients
Fatigue
(constitutional)Persistent tiredness and lack of energy that does not improve with rest, often related to kidney function changes.
Frequency: 30-40% of patients
Abdominal Pain
(gastrointestinal)Pain or discomfort in the belly area, which may be diffuse or localized, sometimes mimicking other abdominal conditions.
Frequency: 30-40% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Allopurinol Therapy
Xanthine oxidase inhibitor that reduces conversion of adenine to 2,8-dihydroxyadenine, preventing crystal formation in kidneys.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Low Purine Diet
Dietary modification to reduce purine intake, decreasing adenine substrate availability for crystal formation.
Additional treatment options
Increased Hydration
High fluid intake (2-3 liters daily) to maintain dilute urine and prevent crystal precipitation in urinary tract.
lifestyleRenal Function Surveillance
Regular monitoring of kidney function through serum creatinine and imaging to detect stone formation or obstruction early.
monitoringStone Removal Procedures
Minimally invasive procedures such as ureteroscopy or lithotripsy to remove obstructing crystals when conservative measures fail.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is 2 8 Dihydroxyadenine Crystalluria C5676845?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Edvardsson VO, Goldfarb DS, Lieske JC, et al. Hereditary causes of kidney stones and chronic kidney disease. Adv Chronic Kidney Dis. 2021;28(5):368-386.
Kidney Disease: Improving Global Outcomes (KDIGO). KDIGO Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease. Kidney Int Suppl. 2018;8(3):91-165.
Cameron JS, Simmonds HA. Hereditary hyperuricosuria and urolithiasis. In: Pediatric Nephrology. Springer, 2022:445-467.
Bouchard L, Gagné S, Viens D, et al. Adenine phosphoribosyltransferase deficiency: a review of clinical presentation and treatment outcomes. Clin Nephrol. 2020;94(3):145-152.
American Urological Association. Medical Management of Kidney Stones: AUA Guideline. J Urol. 2020;203(3):e1-e13.
Millman SA, Stravodimos C, Smith CL. Crystalluria: analysis of a decade of cases. Urol Res. 2019;47(1):23-31.
Fink HA, Wilt TJ, Eidman KE, et al. Medical management to prevent recurrent nephrolithiasis in adults: a systematic review. Ann Intern Med. 2019;171(8):562-577.
Brenner BM, Rector FC. Brenner & Rector's The Kidney. 11th ed. Elsevier; 2019.
European Association of Urology. Guidelines on Urolithiasis. Eur Urol. 2021;79(4):468-494.
National Institute of Diabetes and Digestive and Kidney Diseases. Kidney Stones in Adults. NIH Publication No. 21-4555. 2021.
Medication Comparisons
Compare medications used to treat 2 8 Dihydroxyadenine Crystalluria C5676845. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy