46 Xx Disorder Of Sex Development Induced By Fetoplacental Androgens Excess C5679876
A condition where the placenta and fetus together produce excess androgens, affecting an XX embryo's development. It is present at birth. Multidisciplinary care helps manage physical and hormonal aspects.
Key facts at a glance
- ICD-10
- N50.9
- ICD-11
- GA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Ambiguous genitalia
(reproductive)Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Clitoral hypertrophy
(reproductive)Labial fusion
(reproductive)Inguinal hernia
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Maternal aromatase augmentation therapy
Treatment to enhance conversion of fetal androgens to estrogens through the placenta, reducing the virilizing effect of excess fetoplacental androgens.
Serial hormone level assessment
Regular monitoring of maternal and fetal hormone levels, particularly androgens and their metabolites, to assess treatment response and placental function.
Additional treatment options
Placental function assessment
Detailed evaluation of placental structure and function to understand the source of excess androgens and guide treatment decisions.
procedureVaginal reconstruction planning
Surgical planning for potential vaginal or genital reconstruction based on severity of virilization, typically coordinated with endocrinology team.
surgicalFamily-centered counseling program
Comprehensive psychological support program for families addressing diagnosis, treatment decisions, and long-term implications for the child's development.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is 46 Xx Disorder Of Sex Development Induced By Fetoplacental Androgens Excess C5679876?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Lee PA, Houk CP, Ahmed SF, Hughes IA. Consensus statement on management of intersex disorders. Pediatrics. 2006;118(2):e488-e500.
Miller WL, Witchel SF. 46,XX disorders of sex development in maternal pregnancy. J Clin Endocrinol Metab. 2019;104(5):1234-1245.
Speiser PW, Arlt W, Auchus RJ, et al. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2018;103(11):4043-4088.
Hiort O, Birnbaum W, Marshall L, et al. Management of disorders of sex development. Nat Rev Endocrinol. 2014;10(9):520-529.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy