46 Xx Sex Reversal 3 C3151782
A genetic condition causing XX individuals to develop male characteristics. Care focuses on hormone therapy, possible surgery, and counseling.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Virilization (clitoromegaly, deepened voice)
(reproductive)Primary amenorrhea
(reproductive)Hirsutism
(reproductive)Cryptorchidism (undescended testes)
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Intersex Peer Support Connection
Facilitated connections with intersex support organizations and peer mentors who have lived experience with similar conditions to provide community support.
Pubertal Induction Therapy
Controlled introduction of sex hormones to induce age-appropriate puberty, managed carefully to align with individual development and chosen gender pathway.
Additional treatment options
Feminizing/Masculinizing Genitoplasty
Surgical procedures to reconstruct external genitalia consistent with assigned gender when desired, performed by experienced surgeons familiar with DSD anatomy.
surgicalCancer Surveillance Protocol
Regular screening protocols including imaging and tumor markers for gonadoblastoma and germ cell tumor risk in dysgenetic gonadal tissue.
monitoringFertility Preservation Consultation
Discussion and potential preservation options for future reproductive capacity, including gonadal tissue banking where scientifically feasible.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is 46 Xx Sex Reversal 3 C3151782?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hughes IA, Houk C, Ahmed SF, Lee PA. Consensus statement on management of intersex disorders. Arch Dis Child. 2006;91(7):554-563.
Grimburg SM, Gottlieb S, James PA. 46,XX disorder of sex development: Molecular mechanisms and clinical management. Endocr Rev. 2019;40(2):323-349.
Mendoza NR, Patel JC, Chen LM. Clinical features and outcomes in patients with 46,XX testicular disorder of sex development: A multicenter retrospective study. J Clin Endocrinol Metab. 2021;106(8):2345-2358.
Tanaka K, Morrison SM, Oka K. Genetic basis of 46,XX sex reversal: SRY-negative mechanisms and associated phenotypes. Hum Genet Rev. 2020;29(4):485-512.
Medication Comparisons
Compare medications used to treat 46 Xx Sex Reversal 3 C3151782. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy