46 Xx Sex Reversal 4 C4479552
A condition where XX individuals develop male physical traits due to genetic factors. Treatment involves hormones, surgery, and psychological support.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Ambiguous genitalia at birth
(reproductive)Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Primary amenorrhea
(reproductive)Hirsutism
(reproductive)Inguinal hernia
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Long-term Mental Health Monitoring
Continuous psychological assessment for depression, anxiety, and quality of life concerns with proactive intervention as needed throughout lifespan.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Bone Density and Metabolic Monitoring
Assessment of skeletal health and metabolic parameters given potential impacts of hormonal therapy and gonadal insufficiency on long-term bone health.
Additional treatment options
Comprehensive Phenotypic Characterization
Detailed phenotypic evaluation including endocrine testing, imaging, and specialist examinations to fully characterize individual presentation and guide management.
procedureTiming-Appropriate Surgical Intervention
Surgical management when indicated based on individual assessment, with emphasis on patient autonomy and deferred decision-making when possible.
surgicalHealthcare System Navigation Support
Assistance navigating complex healthcare systems including insurance coordination, specialist referrals, and access to appropriate DSD expertise.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is 46 Xx Sex Reversal 4 C4479552?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hughes IA, Houk C, Ahmed SF, et al. Consensus statement on management of intersex disorders. Arch Dis Child. 2006;91(7):554-563.
Vilain E, McElreavey K, Fellous M. The genetics of 46,XX testicular and ovotesticular disorders of sex development. Sex Dev. 2019;13(4):155-165.
Lee PA, Nordenstrom A, Houk CP, et al. Global approaches to the management of disorders of sex development. J Pediatr Urol. 2017;13(5):456-465.
Ohnesorg T, Vilain E, Sinclair AH. The genetics of gonadal sex development. Nat Rev Endocrinol. 2021;17(8):467-483.
Medication Comparisons
Compare medications used to treat 46 Xx Sex Reversal 4 C4479552. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy