46 Xy Sex Reversal 6 C3151064
A genetic condition where individuals with XY chromosomes develop female physical characteristics due to variations in genes involved in sex development.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Ambiguous genitalia at birth
(reproductive)Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Virilization at puberty
(reproductive)Gynecomastia
(reproductive)Azoospermia leading to infertility
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Puberty Induction Therapy
Controlled hormonal induction of puberty appropriate to gender identity using estrogen or testosterone preparations with careful dose escalation protocols.
Gonadal Dysplasia Screening
Regular ultrasound and tumor marker screening of gonadal tissue for early detection of gonadoblastoma or other malignancies common in sex-reversal conditions.
Additional treatment options
Identity Development Support
Age-appropriate psychological interventions supporting healthy identity formation, addressing body image concerns, and facilitating peer relationships.
psychologicalLaparoscopic Gonad Removal
Minimally invasive surgical approach to remove streak gonads or dysgenetic gonads to prevent malignancy while minimizing surgical morbidity and recovery time.
surgicalBone Health Optimization
Weight-bearing exercise programs and calcium/vitamin D supplementation to maintain skeletal health given potential hormonal deficiencies affecting bone density.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is 46 Xy Sex Reversal 6 C3151064?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hughes IA, Nihoul-Fekete C, Thomas B, Cohen-Kettenis PT. Management of 46 XY disorders of sex development: Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2021.
Ostrer H, Huang Y, Wang Z. Genetic basis of 46 XY gonadal dysgenesis and sex reversal. Endocr Rev. 2020.
Berberoğlu M, Çelik N, Aycan Z. Disorders of sex development: clinical approach and management. J Pediatr Endocrinol Metab. 2019.
Romana M, Goudeau H. SRY gene mutations and 46 XY sex reversal: molecular insights. Nat Genet Med. 2022.
Medication Comparisons
Compare medications used to treat 46 Xy Sex Reversal 6 C3151064. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy