A53 Diffuse Large B Cell Lymphoma C5707085
An aggressive cancer of the immune system affecting infection-fighting white blood cells called B-cells. Treatment typically involves chemotherapy and may include targeted therapies.
Key facts at a glance
- ICD-10
- C83.37
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Lymphadenopathy
(oncologic)Fever
(oncologic)Pain at affected lymph node site
(oncologic)Cutaneous lesions
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
R-CHOP Chemotherapy Protocol
Standard first-line chemotherapy regimen combining rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone. Targets cancer cell proliferation and uses immunotherapy to enhance immune destruction of lymphoma cells.
Central Line Placement for Chemotherapy
Surgical placement of a central venous catheter to facilitate safe administration of chemotherapy agents, blood products, and frequent laboratory monitoring while protecting peripheral veins.
Additional treatment options
Prophylactic Infection Prevention
Antimicrobial prophylaxis and supportive medications to prevent opportunistic infections during immunosuppression. Includes antivirals, antifungals, and antibiotics as indicated.
medicationResponse Assessment and Surveillance
Regular imaging studies, PET scans, and biopsies to assess treatment response and detect early relapse. Includes interim and end-of-treatment staging evaluations.
monitoringSupportive Care and Integrative Oncology
Palliative and supportive services including pain management, nutritional support, counseling, and complementary therapies to improve quality of life during intensive treatment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is A53 Diffuse Large B Cell Lymphoma C5707085?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Zelenetz AD, Gordon LI, Abramson JS, et al. NCCN Guidelines Insights: B-Cell Lymphomas, Version 3.2019. J Natl Compr Canc Netw. 2019.
Sehn LH, Gascoyne RD. Diffuse large B-cell lymphoma: optimizing outcome in the context of clinical and biologic heterogeneity. Blood. 2015.
Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large B-cell lymphoma. N Engl J Med. 2002.
Guan Z, Wang Y, Ma C, et al. Efficacy and safety of R-CHOP versus CHOP in patients with diffuse large B-cell lymphoma: a meta-analysis. Crit Rev Oncol Hematol. 2020.
Medication Comparisons
Compare medications used to treat A53 Diffuse Large B Cell Lymphoma C5707085. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy