Abdominal Obesity Metabolic Syndrome 3 C4014361
A genetic variant of metabolic syndrome with specific inherited characteristics. Shares features with other metabolic syndromes. Treatment focuses on managing weight, blood pressure, and metabolic health.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Elevated Blood Pressure
Hypertension defined as blood pressure reading of 130/80 mmHg or higher, a key component of metabolic syndrome.
Seek immediate care if blood pressure exceeds 180/120 mmHg or if you experience chest pain, severe headache, or vision changes.
Sleep Apnea
Interrupted breathing during sleep, often presenting as loud snoring and daytime drowsiness, common in individuals with abdominal obesity.
Seek immediate care if you experience gasping during sleep, morning headaches, or excessive daytime sleepiness affecting safety.
Abdominal Obesity
(gastrointestinal)Excess fat accumulation around the midsection, measured by waist circumference exceeding 40 inches in men or 35 inches in women.
Frequency: 90-95% of patients
Abnormal Cholesterol Levels
(cardiovascular)Elevated triglycerides and low HDL cholesterol, leading to dyslipidemia associated with metabolic syndrome.
Frequency: 75-85% of patients
Persistent Fatigue
(constitutional)Ongoing tiredness and low energy levels that persist despite adequate rest, often related to insulin resistance.
Frequency: 50-60% of patients
Acanthosis Nigricans
(dermatologic)Dark, thickened velvety skin patches appearing on neck, armpits, and groin, indicating insulin resistance.
Frequency: 30-40% of patients
Difficulty Losing Weight
(constitutional)Persistent difficulty losing weight despite diet and exercise efforts, due to metabolic and hormonal factors.
Frequency: 60-70% of patients
Increased Appetite
(constitutional)Heightened hunger cues, particularly for carbohydrate-rich foods, due to insulin resistance affecting hunger hormones.
Frequency: 45-55% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aggressive Pharmacological Management
Comprehensive medication regimen targeting each metabolic syndrome component with intensification of lipid-lowering therapy, blood pressure medications, and glucose management using multiple agents when single agents are insufficient.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Bariatric and Metabolic Surgery Evaluation
Surgical intervention such as gastric sleeve or gastric bypass may be considered for eligible patients with severe obesity and metabolic syndrome who have failed conservative measures, offering significant metabolic improvements.
Additional treatment options
Sustained Intensive Lifestyle Modification
Long-term comprehensive lifestyle program with ongoing support, frequent follow-up, and behavioral interventions to maintain weight loss and metabolic improvements achieved through other treatment modalities.
lifestyleMultidisciplinary Team Monitoring
Coordinated care with cardiometabolic specialists, endocrinologists, nutritionists, and other healthcare providers for comprehensive monitoring of all metabolic syndrome components and treatment response.
monitoringLong-Term Behavioral Support and Mental Health Care
Ongoing psychological support addressing depression, anxiety, and other mental health conditions common in patients with chronic metabolic disease, providing coping strategies and motivation maintenance for lifelong management.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abdominal Obesity Metabolic Syndrome 3 C4014361?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
International Diabetes Federation. IDF Consensus Definition of the Metabolic Syndrome. Brussels: International Diabetes Federation, 2006.
World Health Organization. Obesity and Overweight. Geneva: WHO, 2021.
National Heart, Lung, and Blood Institute. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. Bethesda: NHLBI, 1998.
Kahn R, Buse J, Ferrannini E, Stern M. The metabolic syndrome: time for a critical appraisal. Diabetes Care. 2005;28(9):2289-2304.
Wormser D, Kaptoge S, Di Angelantonio E, et al. Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular risk. Circulation. 2012;126(6):647-656.
National Institute for Health and Care Excellence. Obesity: Identification, Assessment and Management. NICE Guideline CG189. London: NICE, 2014 (updated 2022).
Alberti KG, Zimmet P, Shaw J. Metabolic syndrome—a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006;23(5):469-480.
Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444(7121):881-887.
Fauci AS, Braunwald E, Kasper DL, et al., eds. Harrison's Principles of Internal Medicine. 21st ed. New York: McGraw-Hill; 2022. Chapter 396: Obesity.
Look AHEAD Research Group. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145-154.
Medication Comparisons
Compare medications used to treat Abdominal Obesity Metabolic Syndrome 3 C4014361. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy