Abdominal Obesity Metabolic Syndrome Quantitative Trait Locus 2 C1854170
A genetic region associated with susceptibility to metabolic syndrome traits. Affects those with inherited predisposition. Lifestyle management is key to reducing associated health risks.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest Discomfort
Pressure, tightness, or pain in the chest area that may indicate underlying heart strain or coronary artery disease.
Seek emergency care immediately for chest pain that is crushing, radiates to arm/jaw, or is accompanied by shortness of breath.
Shortness of Breath
Difficulty breathing or feeling breathless with minimal exertion, potentially indicating cardiovascular complications.
Seek immediate medical attention for sudden severe shortness of breath or breathlessness at rest.
Central Abdominal Fat Accumulation
(metabolic)Excessive fat deposition around the midsection, measured by waist circumference exceeding recommended thresholds.
Frequency: 95-100% of patients
Insulin Resistance
(metabolic)Reduced cellular response to insulin hormone, leading to elevated blood glucose levels and increased diabetes risk.
Frequency: 80-90% of patients
Elevated Blood Pressure
(cardiovascular)Consistently high blood pressure readings, often asymptomatic but increases cardiovascular disease risk.
Frequency: 70-80% of patients
Abnormal Cholesterol Levels
(metabolic)Elevated triglycerides and reduced HDL cholesterol, characteristic of dyslipidemia associated with metabolic syndrome.
Frequency: 75-85% of patients
Sleep Apnea
(respiratory)Interrupted breathing during sleep, often presenting as loud snoring and daytime sleepiness, related to upper airway obstruction.
Frequency: 50-60% of patients
Fatty Liver Disease
(gastrointestinal)Accumulation of fat in liver cells, often detected incidentally on imaging, may progress to liver inflammation.
Frequency: 40-50% of patients
Chronic Fatigue
(constitutional)Persistent tiredness and low energy levels that interfere with daily activities, often related to metabolic dysfunction.
Frequency: 40-50% of patients
Acanthosis Nigricans
(dermatologic)Dark, velvety skin patches typically appearing in body folds and creases, indicating insulin resistance.
Frequency: 20-30% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Genetic risk assessment and surveillance
Comprehensive metabolic monitoring and early intervention protocols based on genetic predisposition to abdominal obesity and metabolic dysfunction.
Preventive weight management
Proactive lifestyle interventions including diet and exercise to mitigate genetic predisposition to metabolic syndrome.
Additional treatment options
Personalized nutrition planning
Dietary approaches tailored to genetic profile emphasizing portion control and macronutrient distribution for optimal metabolic function.
dietaryTargeted exercise prescription
Individualized physical activity program designed to counteract genetic predisposition to abdominal fat deposition.
physical_therapyStress management techniques
Mindfulness and stress-reduction strategies to address cortisol-related metabolic effects that may interact with genetic factors.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abdominal Obesity Metabolic Syndrome Quantitative Trait Locus 2 C1854170?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640-1645.
Pollex RL, Hegele RA. Genetic determinants of the metabolic syndrome. Nat Rev Cardiol. 2016;13(11):639-652.
Wang Y, Rimm EB, Stampfer MJ, Willett WC, Hu FB. Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr. 2005;81(3):555-563.
Wormser D, Kaptoge S, Di Angelantonio E, et al. Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet. 2011;377(9771):1085-1095.
World Health Organization. Global action plan for the prevention and control of noncommunicable diseases 2013-2020. Geneva: WHO; 2013.
Jensen MD, Ryan DH, Apovian CM, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation. 2014;129(25 Suppl 2):S102-138.
Ling C, Rönn T. Epigenetics in human obesity and type 2 diabetes. Cell Metab. 2019;29(5):1028-1044.
International Diabetes Federation. IDF Consensus Definition of Metabolic Syndrome. Brussels: IDF; 2006.
Kusminski CM, Bickel PE, Scherer PE. Targeting adipose tissue in the treatment of obesity-associated diabetes. Nat Rev Drug Discov. 2016;15(9):639-660.
Williams Textbook of Endocrinology. 14th ed. Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, editors. Philadelphia: Elsevier; 2016.
Medication Comparisons
Compare medications used to treat Abdominal Obesity Metabolic Syndrome Quantitative Trait Locus 2 C1854170. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy