Abeta Amyloidosis Dutch Type C2931672
Hereditary cerebral amyloid angiopathy from APP gene mutation. Family-linked condition. Can cause brain hemorrhage and stroke.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Stroke-like episodes
Cognitive decline
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Vitreous opacities
(neurologic)Peripheral neuropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Liver transplantation
Liver transplant is the definitive treatment for hereditary transthyretin amyloidosis as it removes the main source of mutant TTR production. This procedure can halt disease progression when performed early in the disease course.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
TTR gene silencing therapy
RNA interference drugs such as patisiran and inotersen reduce production of mutant transthyretin protein by targeting its messenger RNA. These disease-modifying agents have shown efficacy in slowing neuropathy progression.
Additional treatment options
TTR protein stabilizers
Diflunisal and tafamidis stabilize the transthyretin tetramer, preventing dissociation into amyloidogenic monomers. These agents address both wild-type and variant TTR amyloidosis.
medicationMultidisciplinary surveillance
Regular neurological assessments, cardiac monitoring with echocardiography and biomarkers, and autonomic function testing guide treatment decisions. Imaging studies help assess disease burden and treatment response.
monitoringRehabilitation and assistive devices
Physical therapy maintains muscle strength and mobility while occupational therapy provides adaptive strategies for daily activities. Early intervention preserves functional independence as neuropathy progresses.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Abeta Amyloidosis Dutch Type C2931672?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Greenberg SM, Charidimou A, Martinez-Ramirez S. Hereditary cerebral amyloid angiopathy: The Dutch APP mutation and other familial forms. Neurology. 2018;91(10):e925-e933.
Smith EE, Charidimou A, Ayata C, et al. American Heart Association/American Stroke Association guidelines for the management of cerebral amyloid angiopathy. Stroke. 2022;53(6):e200-e218.
van Etten ES, de Boer I, Boks MP, et al. Natural history of hereditary cerebral amyloid angiopathy Dutch type: A prospective cohort study. Ann Neurol. 2020;88(4):761-774.
Revesz T, Holton JL, Lashley T, Rostagno A, Ghiso J. Cerebral amyloid angiopathy and its mechanisms. Acta Neuropathol. 2019;138(3):337-358.
Medication Comparisons
Compare medications used to treat Abeta Amyloidosis Dutch Type C2931672. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy