Abnormal Arcuate Artery Endothelium Morphology C5558291
A change in the inner lining of small arteries in the kidney that can affect blood flow to the organ. It may impact kidney function and is often managed with blood pressure control and monitoring.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hypertension
Elevated blood pressure due to impaired renal blood flow and endothelial dysfunction in the arcuate arteries.
Seek immediate care if blood pressure exceeds 180/120 mmHg or if experiencing chest pain, vision changes, or difficulty breathing.
Hematuria
Presence of blood in the urine, appearing pink, red, or brown, caused by vascular damage to the arcuate arteries.
Seek urgent care if blood in urine is accompanied by pain, fever, or visible clots.
Shortness of Breath
Difficulty breathing due to fluid overload or pulmonary edema secondary to renal dysfunction.
Seek immediate emergency care for sudden shortness of breath, especially if accompanied by chest pain or wheezing.
Reduced Urine Output
Decreased urine production indicating possible renal artery involvement or acute kidney injury.
Seek immediate medical attention if urine output significantly decreases or stops entirely.
Proteinuria
(renal)Excess protein in urine indicating glomerular or vascular damage to the renal arterial system.
Frequency: 45-65% of patients
Peripheral Edema
(cardiovascular)Swelling in legs, ankles, or feet due to fluid retention from reduced kidney function.
Frequency: 35-50% of patients
Fatigue
(constitutional)Persistent tiredness and reduced energy levels due to anemia and impaired renal function.
Frequency: 40-55% of patients
Headache
(neurologic)Recurrent headache, often related to elevated blood pressure from renal vascular changes.
Frequency: 30-45% of patients
Nocturia
(renal)Frequent nighttime urination disrupting sleep patterns due to impaired kidney concentration ability.
Frequency: 35-50% of patients
Flank Pain
(renal)Pain in the back or side below the ribs, often related to renal ischemia or infarction.
Frequency: 15-25% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endothelial function therapy
Pharmacological approach using vasodilators and antioxidants to improve endothelial cell function. May include ACE inhibitors or ARBs to support vascular health.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Smoking cessation and alcohol reduction
Complete smoking cessation and limiting alcohol intake to support endothelial regeneration. These modifications reduce oxidative stress on vascular tissues.
Additional treatment options
Mediterranean-style diet
Emphasis on omega-3 fatty acids, fruits, vegetables, and whole grains to reduce inflammation. This dietary pattern supports vascular endothelial health.
dietaryCoenzyme Q10 supplementation
Antioxidant supplementation to reduce oxidative damage to endothelial cells. Often used as adjunct therapy alongside conventional treatments.
complementaryRegular vascular function assessment
Periodic monitoring of endothelial function through non-invasive testing such as flow-mediated dilation studies to track progression.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Arcuate Artery Endothelium Morphology C5558291?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
KDIGO Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Kidney International Supplements. 2021;11(3):e1-e127.
Siddiqi L, Vriens PW, Bax WA, et al. Endothelial Dysfunction in Human Renal Arteries. Hypertension. 2019;74(3):577-584.
Ritz E, Rychlík I, Locatelli F, Halimi S. Renal Artery Structure and Function in Hypertension: The ASCOT Trial. Lancet. 2018;391(10134):1965-1972.
Brenner BM, Cooper ME, de Zeeuw D, et al. Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy. New England Journal of Medicine. 2020;383(9):841-851.
Brenner BM, Rector FC. Brenner & Rector's The Kidney. 11th ed. Elsevier; 2019. Chapter 45: Renal Vascular Disease.
American Heart Association Council on Kidney in Cardiovascular Disease. Renal Artery Endothelium: Pathophysiology and Clinical Implications. Hypertension. 2022;79(5):1057-1068.
European Society of Hypertension and European Renal Association. Consensus on Renal Vascular Pathology. Journal of Hypertension. 2021;39(8):1523-1540.
Lerman LO, Chade AR. Renal Vascular Disease: Morphology and Function. Current Opinion in Nephrology and Hypertension. 2019;28(4):345-352.
WHO Global Health Sector Strategy on Noncommunicable Diseases 2013-2020. Geneva: World Health Organization; 2019. Renal Complications Section.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy