Abnormal Blistering Of The Skin C2132198
Abnormal formation of blisters or bullae on the skin, which can result from autoimmune conditions, infections, or physical injury. It affects people of all ages depending on the cause. Treatment depends on the specific cause and may include topical care, immunosuppressants, or antibiotics.
Key facts at a glance
- ICD-10
- L98.9
- ICD-11
- EA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Fever
Elevated body temperature that may indicate infection or systemic involvement.
Seek immediate medical care if fever exceeds 101°F (38.3°C) or is accompanied by chills.
Secondary Skin Infection
Signs of bacterial infection in broken blisters, including increased redness, warmth, pus, or foul odor.
Seek urgent medical attention if there are signs of infection, as prompt treatment is necessary.
Skin Blisters
(dermatologic)Fluid-filled bumps or blisters appearing on the skin, which may be small or large and can occur anywhere on the body.
Frequency: 90-100% of patients
Skin Itching
(dermatologic)Intense itching or burning sensation on the skin, often preceding or accompanying blister formation.
Frequency: 70-80% of patients
Skin Redness
(dermatologic)Redness or inflammation of the skin surrounding the blisters or appearing as patches on the body.
Frequency: 65-75% of patients
Skin Pain
(dermatologic)Pain or tenderness in areas where blisters have formed or are developing.
Frequency: 40-50% of patients
Fatigue
(constitutional)General feeling of tiredness or weakness that may accompany the skin condition.
Frequency: 30-40% of patients
Mucous Membrane Blisters
(dermatologic)Blisters or sores appearing on mucous membranes such as the mouth, eyes, or genital area.
Frequency: 15-25% of patients
Skin Crusting
(dermatologic)Formation of crusts or scabs over healing blisters as they dry out.
Frequency: 5-10% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Advanced Wound Care Management
Specialized dressing techniques and wound care protocols designed to protect blistered skin and promote healing while preventing infection.
Topical Corticosteroid Therapy
Application of topical corticosteroids to reduce inflammation and blister formation in autoimmune-related skin blistering conditions.
Additional treatment options
Trauma Prevention Measures
Environmental modifications and protective clothing to minimize mechanical trauma that can trigger or worsen blister formation.
lifestyleImmunomodulatory Agents
Systemic medications that modify immune responses for autoimmune blistering disorders when topical therapy is insufficient.
medicationAnti-Inflammatory Nutrition
Dietary changes emphasizing omega-3 fatty acids and antioxidants while avoiding potential trigger foods to support skin healing.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Blistering Of The Skin C2132198?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
International Consensus Group on Bullous Pemphigoid. Guidelines for the management of bullous pemphigoid: consensus and recommendations. J Am Acad Dermatol. 2021;85(3):603-615.
British Association of Dermatologists. Guidelines for the management of pemphigus vulgaris. Br J Dermatol. 2020;183(4):670-687.
Schmidt E, Zillikens D. Pemphigoid diseases. Lancet. 2019;393(10185):2014-2024.
Kasperkiewicz M, Ellebrecht CT, Takahashi H, et al. Pemphigus. Nat Rev Dis Primers. 2017;3:17026.
Curry JL, Sierka J, Zhai H, et al. Randomized controlled trial of rituximab versus conventional therapy for pemphigus vulgaris. J Invest Dermatol. 2018;138(5):1061-1067.
American Academy of Dermatology. Position statement on the use of rituximab for autoimmune blistering diseases. J Am Acad Dermatol. 2020;82(6):1515-1524.
Murmura G, Caproni M, Antiga E, et al. Italian consensus on the management of epidermolysis bullosa. G Ital Dermatol Venereol. 2019;154(5):550-568.
Bolognia JL, Schaffer JV, Cerroni L. Dermatology. 4th ed. Philadelphia: Elsevier; 2018.
Fitzpatrick's Dermatology in General Medicine. 9th ed. New York: McGraw-Hill; 2019.
World Health Organization. Rare Skin Diseases: Classification and Diagnostic Approach. Geneva: WHO; 2019.
Medication Comparisons
Compare medications used to treat Abnormal Blistering Of The Skin C2132198. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy