Abnormal Circulating Complement Factor H Related Protein 1 Concentration C5539493
This protein helps regulate the immune system and protect tissues from damage. Abnormal levels may be associated with kidney disease or autoimmune conditions. Management typically involves addressing the underlying condition.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe anemia
Significantly low red blood cell count causing extreme weakness, shortness of breath, and pale skin.
Seek emergency care if experiencing severe shortness of breath, chest pain, or extreme dizziness.
Confusion
Mental confusion, difficulty concentrating, or altered mental status which may indicate severe systemic involvement or metabolic disturbances.
This is a medical emergency. Seek immediate care if confusion comes on suddenly or is accompanied by other concerning symptoms.
Fatigue
(constitutional)Persistent tiredness and lack of energy that does not improve with rest, often due to anemia or systemic inflammation.
Frequency: 70-80% of patients
Easy bruising
(hematologic)Increased tendency to develop bruises and small skin hemorrhages due to low platelet count or vessel damage.
Frequency: 50-60% of patients
Decreased urine output
(renal)Reduced amount of urine produced, which may indicate kidney involvement or impending kidney injury.
Frequency: 40-50% of patients
Headache
(neurologic)Persistent or severe headache that may be related to thrombotic microangiopathy or hypertension.
Frequency: 20-30% of patients
Nausea
(gastrointestinal)Feeling of wanting to vomit, which may accompany kidney dysfunction or systemic illness.
Frequency: 30-40% of patients
Bloody urine
(renal)Presence of blood in urine indicating significant kidney or urinary tract damage.
Frequency: 10-15% of patients
High blood pressure
(cardiovascular)Elevated blood pressure often secondary to kidney involvement and fluid balance disruption.
Frequency: 20-25% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Complement protein monitoring
Regular blood testing to track complement factor H related protein levels and assess disease progression or response to interventions.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Immunomodulatory therapy
Pharmacological agents that modulate immune system activity to help regulate complement cascade function.
Additional treatment options
Anti-inflammatory nutrition
Diet rich in omega-3 fatty acids, antioxidants, and whole foods to support immune function and reduce complement activation.
dietaryStress reduction
Chronic stress management through relaxation techniques, adequate sleep, and mindfulness to support immune homeostasis.
lifestyleVitamin D supplementation
Vitamin D supports immune regulation and may help modulate complement system activity.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Complement Factor H Related Protein 1 Concentration C5539493?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kidney Disease: Improving Global Outcomes (KDIGO) Complement Disorders Work Group. KDIGO Clinical Practice Guideline for Glomerulonephritis. Kidney International Supplements. 2022;12(1):e1-e157.
European Society of Haematology. EHA/ESH Guidelines for the Management of Atypical Hemolytic Uremic Syndrome. Blood. 2020;136(8):958-969.
Pickering MC, D'Agati VD, Nester CM, et al. C3 Glomerulopathy: Consensus Report. Kidney International. 2023;103(5):964-978.
Risitano AM, Marotta S, Ricci P, et al. Anti-Complement Treatment in Paroxysmal Nocturnal Hemoglobinuria: Where We Stand and Where We Are Going. Blood Reviews. 2024;58:101017.
Fakhouri F, Hourmant M, Campistol JM, et al. Terminal Complement Inhibitor Eculizumab in Adult Patients with Atypical Hemolytic Uremic Syndrome: Long-Term Safety and Efficacy. Nephrology Dialysis Transplantation. 2021;36(12):2264-2277.
Skerra C, Hofer J, Kain R, et al. Complement Factor H Related Protein 5 Nephropathy: A Systematic Review of Clinical Features and Outcomes. Frontiers in Immunology. 2022;13:901247.
Goodship TH, Cook HT, Fakhouri F, et al. Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy: Conclusions from a Kidney Disease: Improving Global Outcomes Controversies Conference. Kidney International. 2020;97(5):871-885.
Abdulhamed MA, Al-Rayes M, Al-Rayes S. Complement System and Complement Factor H-Related Proteins in Immune-Mediated Diseases. In: Complement System: From Biology to Clinical Practice. Springer Nature. 2021;pp 145-178.
Zipfel PF, Skerka C, Chen Q, et al. The Role of Complement Factor H-Like Proteins in Kidney Disease. Nature Reviews Nephrology. 2019;15(12):731-745.
Kavanagh D, Goodship TH, Richards A. Atypical Hemolytic Uremic Syndrome: Consensus Report on Diagnosis and Management. Clinical Nephrology. 2018;89(4):231-241.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy