Abnormal Circulating Erythropoietin Concentration C5826395
Abnormal erythropoietin hormone levels affecting red blood cell production. It can cause anemia or excess red blood cells. Treatment depends on whether levels are too high or too low.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest pain
Pain or discomfort in the chest area that may indicate heart strain or reduced oxygen supply to heart muscles.
Seek immediate medical attention if chest pain is severe, radiating, or accompanied by shortness of breath, sweating, or nausea.
Fatigue and weakness
(constitutional)Persistent tiredness and lack of energy due to reduced oxygen-carrying capacity from abnormal red blood cell production.
Frequency: 70-90% of patients
Shortness of breath
(respiratory)Difficulty breathing or breathlessness, especially during physical activity, caused by inadequate oxygen delivery to tissues.
Frequency: 60-80% of patients
Dizziness
(neurologic)Feeling lightheaded, unsteady, or faint, often worsening when standing up quickly.
Frequency: 50-70% of patients
Abnormal skin coloration
(dermatologic)Unusually pale skin (with low EPO) or ruddy, reddish complexion (with high EPO) due to changes in red blood cell count.
Frequency: 40-60% of patients
Headache
(neurologic)Persistent or recurrent headaches, often due to altered blood viscosity or oxygen deprivation to brain tissues.
Frequency: 30-50% of patients
Heart palpitations
(cardiovascular)Awareness of rapid, forceful, or irregular heartbeat as the heart works harder to compensate for oxygen deficiency.
Frequency: 30-50% of patients
High blood pressure
(cardiovascular)Elevated blood pressure, particularly associated with elevated erythropoietin levels causing increased blood viscosity.
Frequency: 40-60% of patients
Nausea or loss of appetite
(gastrointestinal)Feeling sick to the stomach or reduced desire to eat, which may accompany the metabolic effects of abnormal EPO levels.
Frequency: 15-25% of patients
Difficulty concentrating
(neurologic)Mental fog, trouble focusing, or reduced cognitive function due to chronic oxygen deprivation to brain tissues.
Frequency: 5-15% of patients
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy