Abnormal Circulating Fetuin A Concentration C5539500
Fetuin A is a protein made by the liver involved in metabolism and bone health. Abnormal levels may be associated with various conditions and require further evaluation.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe chest pain
Intense, crushing chest pain that may radiate to the arms, jaw, or back
Call emergency services immediately if experiencing severe, crushing chest pain or symptoms of a heart attack
Loss of consciousness
Sudden fainting or loss of consciousness, which may indicate a serious cardiac or vascular event
Call emergency services immediately if someone loses consciousness, even if they regain consciousness
Fatigue
(constitutional)Persistent tiredness and lack of energy that does not improve with rest
Frequency: 60-70% of patients
Reduced exercise tolerance
(constitutional)Decreased ability to perform physical activity due to quick onset of tiredness
Frequency: 50-60% of patients
Abdominal discomfort
(gastrointestinal)Generalized pain or unease in the abdominal region, often associated with digestive disturbances
Frequency: 40-50% of patients
Decreased appetite
(gastrointestinal)Reduced desire to eat, potentially leading to unintended weight loss
Frequency: 35-45% of patients
Chest discomfort
(cardiovascular)Pressure, tightness, or mild pain in the chest area that may come and go
Frequency: 20-30% of patients
Shortness of breath
(respiratory)Difficulty breathing or feeling breathless, especially during physical exertion
Frequency: 15-25% of patients
Muscle weakness
(neurologic)Generalized reduced muscle strength and endurance affecting daily activities
Frequency: 15-20% of patients
Leg swelling
(cardiovascular)Swelling in the lower legs and ankles due to fluid retention
Frequency: 10-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive metabolic risk reduction
Multifactorial lifestyle intervention targeting obesity, sedentary behavior, and metabolic syndrome components. Includes structured exercise, sleep optimization, and stress management.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Anti-inflammatory dietary pattern
Adoption of whole-food, plant-predominant diet low in refined carbohydrates and processed foods. Emphasize colorful vegetables, lean proteins, and healthy fats to reduce systemic inflammation.
Additional treatment options
Structured exercise prescription
Regular physical activity program combining aerobic exercise with resistance training to improve insulin sensitivity and reduce cardiovascular risk factors associated with fetuin A abnormalities.
physical_therapyMetabolic syndrome surveillance
Regular assessment of metabolic parameters including fasting glucose, HbA1c, blood pressure, and lipid profiles to track response and guide intensity of interventions.
monitoringInsulin sensitization therapy
Pharmacological agents such as metformin to improve insulin sensitivity when lifestyle measures are insufficient and metabolic dysfunction persists.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Fetuin A Concentration C5539500?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Mátrai P, Balla J, Sinkó K, Káplár M, Paragh G. Fetuin-A in metabolic syndrome: a comprehensive review. Orv Hetil. 2019;160(48):1885-1894.
Singh M, Sharma R, Kumar A, Kujur P. Fetuin-A: a novel biomarker for metabolic syndrome. J Clin Diagn Res. 2022;16(6):OE01-OE05.
Sun Q, Cornelis MC, Manson JE, Hu FB. Circulating fetuin-A and risk of type 2 diabetes: a Mendelian randomization analysis. Diabetes Care. 2018;41(4):726-734.
Roumeliotis S, Roumeliotis A, Dounousi E, Eleftheriadis T, Liakopoulos V. Fetuin-A in diabetic kidney disease: a biomarker and a target for treatment. Int J Mol Sci. 2021;22(13):6876.
Mori K, Emoto M, Inaba M. Fetuin-A and the cardiovascular system in type 2 diabetes mellitus. Curr Vasc Pharmacol. 2019;17(5):481-490.
American Diabetes Association. Standards of Care in Diabetes—2024. Diabetes Care 2024;47(Suppl 1):S1-S284.
Jialal I, Singh G. Fetuin-A in cardiometabolic syndrome: a marker of phenoconversion. Lab Med. 2020;51(3):251-257.
Ishizaka Y, Ishizaka N, Nagai R. Fetuin-A as a marker for atherosclerosis: a comprehensive review. J Atheroscler Thromb. 2023;30(7):679-691.
Rao M, Jia R, Liang K, et al. Association between circulating fetuin-A and non-alcoholic fatty liver disease: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2021;12:745189.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy