Abnormal Circulating Fibroblast Growth Factor 23 Concentration C5937256
FGF23 is a hormone that helps regulate phosphate levels and bone health. Abnormal levels can affect kidney function and bone metabolism, requiring careful monitoring and management.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Phosphate restriction
Dietary modification to limit phosphate intake through reduced consumption of processed foods, dairy products, nuts, and carbonated beverages. Fresh food preparation preferred.
Phosphate binder therapy
Administration of phosphate-binding agents with meals to reduce intestinal phosphate absorption. Various formulations available including calcium-based and non-calcium binders.
Additional treatment options
Phosphate and calcium homeostasis monitoring
Regular laboratory assessment of serum phosphate, calcium, and PTH levels to guide dietary and pharmacological interventions and prevent complications.
monitoringActive vitamin D supplementation
Vitamin D sterols such as calcitriol or analogs may be prescribed to manage secondary hyperparathyroidism and mineral bone disease associated with FGF23 elevation.
medicationDialysis optimization
For patients with CKD requiring dialysis, optimization of dialysis prescription including phosphate removal efficiency and dialysate calcium concentration.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Fibroblast Growth Factor 23 Concentration C5937256?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Haffner D, Emma F, Eastwood DM, et al. Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia. Nat Rev Nephrol. 2019.
Liu ES, Thoonen R, Petit I, et al. Molecular mechanisms of FGF23 expression and regulation in normal and pathological conditions. Endocrinology. 2021.
Carpenter TO, Imel EA, Ruppe MD, et al. Randomized trial of Burosumab versus conventional therapy in children with X-linked hypophosphatemia. J Bone Miner Res. 2022.
Tencerova I, Frost M, Felsenberg D, et al. Fibroblast growth factor 23 in phosphate disorders: a systematic review and meta-analysis. Bone. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy