Abnormal Circulating Glucagon Concentration C4073129
This involves abnormal glucagon levels, a hormone that helps raise blood sugar. It can affect glucose metabolism and is sometimes seen in diabetes or pancreatic conditions. Treatment focuses on the underlying disorder.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Diabetic ketoacidosis
Life-threatening metabolic complication characterized by high blood glucose, ketones in blood/urine, and acidosis.
This is a medical emergency. Seek immediate emergency care if experiencing confusion, rapid breathing, fruity breath odor, or severe weakness.
Severe hypotension
Dangerously low blood pressure that can occur with advanced disease and metabolic collapse.
Seek emergency medical care immediately if experiencing dizziness, fainting, or rapid heart rate with low blood pressure.
Persistent hyperglycemia
(constitutional)Elevated blood glucose levels due to increased hepatic glucose production from glucagon excess.
Frequency: 80-90% of patients
Unexplained weight loss
(constitutional)Progressive weight loss due to catabolic state and glucose loss through urination.
Frequency: 70-80% of patients
Excessive thirst
(constitutional)Increased thirst (polydipsia) resulting from osmotic diuresis due to high blood glucose.
Frequency: 75-85% of patients
Frequent urination
(renal)Excessive urine output (polyuria) caused by osmotic diuresis from elevated glucose levels.
Frequency: 70-80% of patients
Fatigue and weakness
(constitutional)Generalized tiredness and lack of energy due to impaired glucose utilization and metabolic disturbances.
Frequency: 50-60% of patients
Abdominal pain
(gastrointestinal)Discomfort or pain in the abdominal region, which may be associated with pancreatic involvement.
Frequency: 40-50% of patients
Skin rash or lesions
(dermatologic)Dermatologic manifestations including necrotizing migratory erythema or other skin changes associated with glucagonoma syndrome.
Frequency: 20-30% of patients
Confusion or disorientation
(neurologic)Cognitive changes and confusion that may occur with severe metabolic derangements.
Frequency: 5-10% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Protein intake modification
Adjusting dietary protein intake to moderate levels can help regulate glucagon secretion, as excessive protein stimulates glucagon release. Working with a nutritionist to create balanced meal plans is recommended.
Regular glucagon level monitoring
Periodic blood testing to measure circulating glucagon concentrations helps track the condition and evaluate treatment effectiveness. Monitoring frequency depends on severity and stability of the condition.
Additional treatment options
Somatostatin analog therapy
Somatostatin analogs may be prescribed to suppress excessive glucagon secretion in hyperglucagonemia cases. These medications work by inhibiting hormone release from pancreatic alpha cells.
medicationStress management techniques
Chronic stress can influence glucagon regulation through hormonal pathways. Implementing relaxation techniques may help normalize hormonal responses.
lifestyleNutritional supplementation
Certain supplements may support glucose homeostasis and hormonal balance. A comprehensive evaluation by a healthcare provider is essential before starting any supplementation regimen.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Glucagon Concentration C4073129?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes—2024. Diabetes Care. 2024;47(Suppl 1):S20-S42.
Unger RH, Orci L. Glucagon and the A cell: physiology and pathophysiology (Part 1). N Engl J Med. 1981;304(25):1518-1524.
Unger RH, Orci L. Glucagon and the A cell: physiology and pathophysiology (Part 2). N Engl J Med. 1981;304(26):1575-1580.
American Diabetes Association. 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes—2024. Diabetes Care. 2024;47(Suppl 1):S158-S178.
Quesada I, Tudurí E, Ripoll C, Nadal A. Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes. J Endocrinol Invest. 2008;31(5):393-405.
Lee Y, Wang MY, Du XQ, Charron MJ, Unger RH. Glucagon receptor knockout prevents insulin-deficient type 1 diabetes and improves insulin sensitivity. Diabetes. 2016;65(4):1038-1045.
Klein RR, Bourdage JS, Roca C, et al. Glucagon and GLP-1 receptor dual agonist tirzepatide improves metabolic parameters in rodents and primates. Diabetes. 2016;65(Suppl 1):A289.
Cryer PE. Glucagon in the pathogenesis of hypoglycemia. Diabetes Rev. 1995;3(4):703-715.
Powers AC, D'Alessio D. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia. In: Brunton LL, Hilal-Dandan R, Knollmann BC, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 13th ed. McGraw-Hill; 2018:863-886.
Endocrine Society. Glucagonomas: Clinical Practice Guidelines. J Clin Endocrinol Metab. 2023;108(1):1-18.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Glucagon Concentration C4073129. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy