Abnormal Circulating Growth Hormone Concentration C5139300
A hormonal condition where growth hormone, which controls growth and metabolism, is present at abnormal levels in the blood.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Somatostatin analog therapy
Somatostatin analogs such as octreotide or lanreotide inhibit growth hormone secretion from pituitary adenomas. These agents are typically administered as monthly injections and help normalize GH levels in many patients.
Transsphenoidal pituitary surgery
Surgical removal of GH-secreting pituitary adenoma through the sphenoid sinus provides the best chance for cure. Endoscopic approaches have improved outcomes and reduced complications compared to traditional methods.
Additional treatment options
GH receptor antagonist
Pegvisomant blocks growth hormone receptors, effectively controlling symptoms even when GH levels remain elevated. This treatment is particularly useful when other therapies have failed or are contraindicated.
medicationEndocrine monitoring and imaging
Regular IGF-1 measurements and pituitary MRI imaging track disease progression and treatment efficacy. Serial visual field testing monitors for tumor compression effects.
monitoringCardiovascular risk management
Aggressive management of hypertension, diabetes, and lipid abnormalities reduces cardiovascular complications associated with acromegaly. Regular exercise and smoking cessation are essential.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Growth Hormone Concentration C5139300?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Melmed S, Casanueva FF, Klibanski A, et al. A consensus on the diagnosis and treatment of acromegaly cardiovascular complications. Endocr Pract. 2021.
Giustina A, Chanson P, Kleinberg D, et al. Expert consensus on the assessment and management of adult growth hormone deficiency. Nat Rev Endocrinol. 2020.
Johannsson G, Ragnarsson O, Bergthorsdottir R. Long-term effects of growth hormone replacement in adults with growth hormone deficiency. J Clin Endocrinol Metab. 2022.
Puig-Domingo M, Marazuela M, Yildiz BO, et al. Cardiovascular outcomes in acromegaly patients treated with somatostatin analogs: a systematic review and meta-analysis. Pituitary. 2023.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Growth Hormone Concentration C5139300. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy