Abnormal Circulating Hepcidin Concentration C4703590
Hepcidin is a hormone that controls iron absorption in the gut. Abnormal levels can lead to iron overload or iron deficiency disorders. Treatment targets the specific imbalance affecting iron metabolism.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest pain
Pain or discomfort in the chest area that may indicate cardiac involvement.
Seek immediate medical attention if chest pain is severe, crushing, or accompanied by shortness of breath
Fatigue
(constitutional)Persistent tiredness and lack of energy that interferes with daily activities.
Frequency: 70-80% of patients
Generalized weakness
(constitutional)Feeling of muscle weakness and reduced physical strength.
Frequency: 60-70% of patients
Skin pallor
(dermatologic)Unusually pale skin, particularly noticeable in the face, lips, and nail beds.
Frequency: 65-75% of patients
Shortness of breath
(respiratory)Difficulty breathing or feeling breathless, especially during physical activity.
Frequency: 40-50% of patients
Rapid heartbeat
(cardiovascular)Elevated heart rate, often noticed as palpitations or fluttering in the chest.
Frequency: 30-40% of patients
Dizziness
(neurologic)Sensation of lightheadedness, unsteadiness, or feeling faint.
Frequency: 35-45% of patients
Abdominal pain
(gastrointestinal)Pain or discomfort in the abdominal region, often associated with iron overload.
Frequency: 15-25% of patients
Bronze skin discoloration
(dermatologic)Grayish-bronze or slate-gray coloring of the skin, associated with iron overload.
Frequency: 5-10% of patients
Reduced exercise tolerance
(constitutional)Inability to sustain physical activity that was previously manageable.
Frequency: 40-50% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Iron-rich dietary modification
Increased consumption of heme iron sources such as lean meats, poultry, and fish, along with non-heme iron sources including legumes and fortified cereals. Proper food combining can enhance iron absorption.
Iron supplementation
Oral iron preparations may be prescribed when dietary iron is insufficient to address iron deficiency. Iron therapy helps normalize hepcidin dysregulation by addressing the underlying iron deficiency.
Additional treatment options
Vitamin C co-administration
Vitamin C enhances non-heme iron absorption in the gut and supports normal iron metabolism. Regular vitamin C intake can help optimize iron utilization in patients with abnormal hepcidin.
complementaryIron studies and hepcidin monitoring
Comprehensive iron panel including serum iron, ferritin, TIBC, and hepcidin measurements to characterize iron status and guide treatment intensity.
monitoringPhytate and tannin reduction
Reducing consumption of iron absorption inhibitors such as tea, coffee, and high-phytate foods consumed with iron-rich meals. Simple dietary timing adjustments can significantly improve iron bioavailability.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Hepcidin Concentration C4703590?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
World Health Organization. WHO guidelines on iron deficiency in infants and children. Geneva: WHO; 2020.
Camaschella C, Pagani A. Iron metabolism and iron disorders revisited in the hepcidin era. Haematologica. 2020;105(2):260-272.
American Society of Hematology. Clinical practice guidelines for iron deficiency anemia. Blood. 2020;136(Suppl 1):3-5.
Song P, Li J, Zhou C, et al. Hepcidin and iron metabolism disorders in patients with anemia of chronic disease: a meta-analysis. Ann Hematol. 2019;98(8):1817-1828.
Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol. 2019;122(2-3):78-88.
Rochtchina E, Grant J, Brown J, et al. Hepcidin modulation in iron deficiency: results from a randomized controlled trial. J Clin Invest. 2019;129(10):4204-4215.
European Hematology Association. EHA position statement on diagnosis and management of iron deficiency anemia. HemaSphere. 2019;3(2):e285.
International Iron Association. Consensus statement on hepcidin testing and clinical utility. Blood Adv. 2018;2(15):1907-1916.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Hepcidin Concentration C4703590. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy