Abnormal Circulating Hyaluronic Acid Concentration C4531276
Hyaluronic acid is a substance involved in skin and joint health, and liver scarring. Elevated levels may indicate liver fibrosis or connective tissue conditions. Doctors use it along with other tests to assess the condition.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- hepatobiliary
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Yellowing of skin or eyes
Jaundice causing yellow discoloration of the skin and whites of the eyes.
Seek immediate medical attention if jaundice appears suddenly or is accompanied by severe weakness, dark urine, or pale stools.
Abdominal swelling
Buildup of fluid in the abdomen (ascites) causing visible swelling and fullness.
Seek prompt medical care if abdominal swelling develops suddenly, is accompanied by pain, or makes it difficult to breathe.
Confusion or difficulty concentrating
Mental confusion, difficulty focusing, or personality changes due to hepatic encephalopathy.
Seek emergency care immediately if confusion, disorientation, or severe drowsiness occurs, as this can indicate serious liver dysfunction.
Persistent fatigue
(constitutional)Persistent feeling of tiredness and low energy that does not improve with rest.
Frequency: 70-80% of patients
Abdominal discomfort
(gastrointestinal)General discomfort or dull ache in the abdominal area, often in the upper right quadrant.
Frequency: 50-60% of patients
Loss of appetite
(gastrointestinal)Reduced desire to eat, leading to decreased food intake.
Frequency: 40-50% of patients
Spider angiomas
(dermatologic)Small, spider-like blood vessels visible on the skin, typically on the face, chest, or arms.
Frequency: 30-40% of patients
Unexplained weight loss
(constitutional)Losing weight without trying, often due to decreased appetite and metabolism changes.
Frequency: 30-40% of patients
Skin itching
(dermatologic)Generalized itching (pruritus) without visible skin rash, often worse at night.
Frequency: 15-20% of patients
Easy bruising
(hematologic)Bruising or bleeding more easily than normal due to reduced liver function and clotting factor production.
Frequency: 30-40% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive biomarker tracking
Regular assessment of hyaluronic acid levels along with related inflammatory markers to establish baseline values and monitor trends over time.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Collagen precursor supplementation
Oral supplements containing compounds that support endogenous hyaluronic acid production and skin/joint health. Includes ingredients like vitamin C and amino acids.
Additional treatment options
Anti-inflammatory nutrition plan
Dietary approach emphasizing whole foods, omega-3 fatty acids, and antioxidants to reduce systemic inflammation that may affect hyaluronic acid metabolism.
dietaryHydration optimization
Increased water intake to support proper distribution and function of hyaluronic acid throughout connective tissues and joints.
lifestyleJoint mobility and strengthening program
Targeted exercises to maintain joint health and support connective tissue function. Includes range of motion work and progressive resistance training.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Hyaluronic Acid Concentration C4531276?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
European Association for the Study of the Liver. EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis - 2021 update. J Hepatol. 2021;75(3):659-689.
AASLD Expert Panel. AASLD Guidelines for the Treatment of Hepatocellular Carcinoma. Hepatology. 2022;75(4):1012-1054.
Poynard T, Morra R, Halfon P, et al. Meta-analyses of FibroTest and ActiTest in chronic hepatitis C: the influence of genotype, viral load, ALT level, and newly developed algorithms. J Viral Hepat. 2011;18(8):535-543.
Rosenberg WM, Voelker M, Thiel R, et al. Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology. 2004;127(6):1704-1713.
Lin ZH, Xin YN, Dong QJ, et al. Performance of the aspartate aminotransferase-to-platelet ratio index for the staging of hepatitis C-related fibrosis: an updated meta-analysis. Hepatology. 2011;53(3):726-736.
Mytilinaios DG, Marvaki S, Saridi M, et al. Hyaluronic acid serum levels in patients with liver fibrosis. J Clin Lab Anal. 2012;26(4):267-271.
Castera L. Noninvasive methods to assess liver disease in patients with hepatitis B or C. Gastroenterology. 2012;142(6):1293-1302.e4.
European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Hepatitis B virus infection. J Hepatol. 2017;66(2):398-430.
Bedossa P, Carrat F. Liver fibrosis: current status of invasive methods and non-invasive biomarkers. J Hepatol. 2012;56(5):1170-1180.
Houot M, Ngo Y, Munteanu M, Poynard T. Systematic review of biomarker-based prognostic models for chronic liver disease. Hepatology. 2016;64(5):1535-1546.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy