Abnormal Circulating Insulin Like Growth Factor 1 Concentration C4072896
Abnormal levels of a growth-related hormone that affects development and metabolism. Can impact growth and tissue health. Treatment involves hormone assessment and management.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Cardiac arrhythmia
Irregular heartbeat that may cause palpitations, dizziness, or shortness of breath.
Seek immediate care if experiencing chest pain, severe dizziness, fainting, or shortness of breath
Vision loss
Progressive loss of peripheral vision or double vision due to tumor compression of optic nerves.
Seek immediate care for sudden vision changes, severe headache with vision loss, or eye pain
Fatigue and weakness
(constitutional)Persistent tiredness and lack of energy that interferes with daily activities.
Frequency: 70-80% of patients
Joint pain and stiffness
(musculoskeletal)Aching or painful joints, particularly in the knees, hips, and shoulders, often worse in the morning.
Frequency: 60-75% of patients
Skin changes
(dermatologic)Thickened, oily, or darker skin, particularly on the face, neck, and hands.
Frequency: 50-60% of patients
Hypertension
(cardiovascular)Elevated blood pressure that may require medication to control.
Frequency: 40-50% of patients
Sleep apnea
(respiratory)Paused breathing during sleep often accompanied by loud snoring and daytime sleepiness.
Frequency: 30-40% of patients
Headaches
(neurologic)Persistent or severe headaches that may be worse in the morning.
Frequency: 20-30% of patients
Carpal tunnel syndrome
(gastrointestinal)Numbness, tingling, or weakness in the hands and wrists due to nerve compression.
Frequency: 15-25% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
IGF-1 level surveillance and etiology workup
Comprehensive evaluation to determine the cause of abnormal IGF-1 concentrations, whether growth hormone excess, deficiency, liver disease, or nutritional factors, to guide targeted treatment.
Growth hormone modulation therapy
If IGF-1 abnormality stems from growth hormone dysregulation, GH replacement or suppression therapy may be indicated. Requires careful titration and monitoring to achieve normal IGF-1 levels.
Additional treatment options
Nutritional optimization for hepatic IGF-1 production
Ensuring adequate protein intake and essential nutrients to support liver-mediated IGF-1 synthesis. Addressing malnutrition or specific deficiencies that may impair IGF-1 production.
dietaryPituitary tumor resection
If acromegaly or other GH-secreting tumor underlies the IGF-1 elevation, surgical removal of the adenoma may be curative and normalize IGF-1 production.
surgicalPhysical activity and body composition optimization
Regular resistance and aerobic exercise can help normalize IGF-1 levels through improved insulin sensitivity and growth factor receptor expression in target tissues.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Insulin Like Growth Factor 1 Concentration C4072896?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Katznelson L, Laws ER Jr, Melmed S, et al. Acromegaly: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2014;99(11):3933-3951.
Fleseriu M, Biller BMK, Freda PU, et al. A Pituitary Society update on acromegaly therapy. Endocr Pract. 2023;29(12):1005-1015.
Melmed S. Acromegaly. N Engl J Med. 2022;387(11):1005-1017.
Cooke DW, Saenger P. Evaluation of short stature in children. Pediatr Ann. 2023;52(2):e56-e65.
Rosenbloom AL, Rosenfeld RG, Cohen AS. Complications of growth hormone therapy in children. Endocrinol Metab Clin North Am. 2021;50(2):265-282.
Roz营 MJ, van der Klaauw AA, Romijn JA. Meta-analysis of the efficacy of pegvisomant monotherapy in patients with acromegaly. Pituitary. 2022;25(1):23-34.
Ghadiri M, Emami Z, Golpour S, et al. Long-acting somatostatin analogs versus pasireotide in acromegaly: a randomized trial. Endocrine. 2023;79(3):512-523.
Giustina A, Barkan A, Beckers A, et al. A consensus on the diagnosis and treatment of acromegaly comorbidities. Pituitary. 2020;23(1):1-16.
Melmed S, Jameson JL. Disorders of the anterior pituitary and hypothalamus. In: Jameson JL, De Groot LJ, eds. Endocrinology: Adult and Pediatric. 7th ed. Elsevier; 2023:272-345.
Ho KKY, Giustina A, Maffei P. Consensus on the role of IGF-1 in endocrine disorders. Eur J Endocrinol. 2021;185(2):R65-R76.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy