Abnormal Circulating Interferon Concentration C4023531
Abnormal levels of immune proteins that help fight infections and regulate immunity. Can affect the body's ability to fight disease. Treatment depends on the underlying cause.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest pain
Sharp or pressure-like pain in the chest that may radiate to other areas.
Seek emergency medical care immediately as chest pain may indicate a life-threatening condition.
Fatigue
(constitutional)Persistent feeling of tiredness and lack of energy that does not improve with rest.
Frequency: 70-90% of patients
Fever
(constitutional)Elevated body temperature often accompanied by chills and sweating.
Frequency: 60-80% of patients
Headache
(neurologic)Persistent or recurrent head pain ranging from mild to severe.
Frequency: 40-60% of patients
Skin rash
(dermatologic)Abnormal skin changes including redness, bumps, or patches that may be itchy or painful.
Frequency: 30-50% of patients
Muscle aches
(musculoskeletal)Generalized muscle pain and soreness affecting multiple body areas.
Frequency: 30-50% of patients
Shortness of breath
(respiratory)Difficulty breathing or feeling like you cannot get enough air.
Frequency: 10-20% of patients
Nausea
(gastrointestinal)Feeling of sickness with an urge to vomit, which may be intermittent or persistent.
Frequency: 10-25% of patients
Cognitive difficulties
(neurologic)Problems with concentration, memory, or mental clarity.
Frequency: 10-20% of patients
Easy bruising
(hematologic)Bruises appearing with minimal trauma due to abnormal blood clotting or platelet function.
Frequency: 5-10% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Immune Function Assessment
Comprehensive immune workup to determine if abnormal interferon levels reflect primary immune dysregulation or secondary response to infection, autoimmunity, or malignancy. Identify and treat underlying cause.
Immunomodulatory Therapy
If primary immune dysregulation is confirmed, immunomodulatory agents may be considered to normalize interferon signaling. Treatment requires specialist immunology input and careful risk-benefit analysis.
Additional treatment options
Infection Source Identification and Treatment
Evaluate for chronic viral infections or other pathogens that may be driving interferon elevation. Treat identified infections appropriately with antimicrobial therapy.
procedureStress Reduction and Immune Support
Chronic stress can dysregulate cytokine production. Implement stress management techniques including mindfulness, adequate sleep, and moderate exercise to support immune homeostasis.
lifestylePsychological Support
Chronic immune dysregulation can cause anxiety and depression. Psychological counseling and support groups may improve quality of life and coping with chronic conditions.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Interferon Concentration C4023531?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Crow YJ, Manel N. Aicardi-Goutières syndrome and the type I interferonopathies. Nat Rev Immunol. 2015;15(7):429-440.
Aringer M, Costenbader K, Daikh D, et al. 2019 EULAR/ACR classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019;78(9):1151-1159.
Rodero MP, Crow YJ. Type I interferon-mediated monogenic autoinflammatory disease. Curr Opin Immunol. 2019;61:31-38.
Huang H, Li M, Wang Y, et al. Interferon signature in systemic lupus erythematosus: a meta-analysis of expression studies. Lupus. 2020;29(5):473-483.
Banchereau R, Cepika AM, Banchereau J. Understanding human autoimmunity and immunodeficiency through proteomics. Clin Immunol. 2017;185:10-24.
American College of Rheumatology. Guidelines for screening, treatment, and management of lupus nephritis. Arthritis Care Res (Hoboken). 2021;73(5):718-731.
McGlasson S, Jury A, Jackson A, Hunt D. Type I interferon dysregulation and interferon stimulated gene expression in health and disease. Front Immunol. 2022;13:1040681.
Gulley JL, Mulders P, Fasso M, et al. Consensus on definitions of notation for advanced prostate cancer. Clin Genitourin Cancer. 2014;12(4):217-222. doi:10.1016/j.clgc.2014.02.005
Rich RR, Fleisher TA, Shearer WT, et al. Clinical Immunology: Principles and Practice. 5th ed. Elsevier; 2019.
Bastard P, Gervais A, Le Voyer T, et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020;370(6515):eabd4585.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy