Abnormal Circulating Lipid Concentration C4025650
Abnormal lipid levels in the blood involve too much or too little fat. This can affect heart and blood vessel health. Treatment often includes diet changes and sometimes medication.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest Pain (Angina)
Pressure or squeezing pain in the chest due to reduced blood flow to the heart muscle.
Seek emergency care immediately if chest pain is severe, prolonged, or accompanied by shortness of breath, sweating, or nausea.
Severe Abdominal Pain
Intense upper abdominal pain caused by inflammation of the pancreas (pancreatitis) due to high triglyceride levels.
Seek immediate medical attention for sudden, severe abdominal pain.
Skin Xanthomas
(dermatologic)Yellowish, fatty deposits that appear as bumps on the skin, commonly found on eyelids, tendons, and hands.
Frequency: 30-50% of patients
Corneal Arcus
(ophthalmologic)Gray or white ring visible around the cornea of the eye due to lipid deposits.
Frequency: 60-70% of patients over age 40
Shortness of Breath
(cardiovascular)Difficulty breathing or feeling winded, especially during physical activity, due to heart strain.
Frequency: 25-35% of patients
Persistent Fatigue
(constitutional)Feeling unusually tired or lacking energy, even after adequate rest.
Frequency: 40-50% of patients
Leg Pain While Walking
(vascular)Cramplike pain in the legs during walking or exercise due to reduced blood flow (claudication).
Frequency: 10-15% of patients
Memory Difficulties
(neurologic)Trouble concentrating or mild memory issues associated with reduced blood flow to the brain.
Frequency: 10-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Mediterranean-style dietary pattern
Emphasis on monounsaturated fats, omega-3 fatty acids, and fiber-rich foods while reducing saturated fats and refined carbohydrates. This approach helps normalize circulating lipid concentrations through evidence-based nutritional modifications.
Structured physical activity program
Regular aerobic exercise of moderate intensity for at least 150 minutes weekly, which improves lipid metabolism and helps regulate circulating lipid concentrations through enhanced enzymatic activity.
Additional treatment options
Lipid-lowering pharmacotherapy
Statins and other lipid-modifying agents may be prescribed when lifestyle interventions are insufficient to normalize circulating lipid concentrations, with regular monitoring of efficacy and tolerability.
medicationRegular lipid panel monitoring
Scheduled blood testing to assess circulating lipid concentrations and treatment response, allowing for timely adjustments to therapeutic interventions.
monitoringWeight management and body composition optimization
Achieving and maintaining healthy body weight through balanced nutrition and regular physical activity, which positively influences lipid metabolism and circulating concentrations.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Lipid Concentration C4025650?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol. Circulation. 2019;139(25):e1082-e1143.
Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41(1):111-188.
Feingold KR. Introduction to Lipids and Lipoproteins. In: Feingold KR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486-2497.
Fauci AS, Kasper DL, Hauser SL, et al., editors. Harrison's Principles of Internal Medicine. 21st ed. New York: McGraw-Hill; 2022. Chapter 406: Disorders of Lipid Metabolism.
American Diabetes Association. 10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes—2022. Diabetes Care. 2022;45(Suppl 1):S144-S174.
Silverman MG, Ference BA, Im K, et al. Association between lowering LDL-C and cardiovascular risk reduction among different therapeutic interventions: a systematic review and meta-analysis. JAMA. 2016;316(12):1289-1297.
Stone NJ, Robinson J, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2):S1-45.
Ridker PM, Revkin J, Amarenco P, et al. Cardiovascular efficacy and safety of bococizumab in high-risk patients. N Engl J Med. 2017;376(16):1527-1539.
Centers for Disease Control and Prevention. Cholesterol: Facts & Statistics. Atlanta, GA: CDC; 2023.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Lipid Concentration C4025650. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy