Abnormal Circulating Lipoprotein A Concentration C5936894
Lipoprotein(a) is a particle that carries cholesterol in blood. High levels may raise heart disease risk. Doctors monitor levels and recommend heart-healthy habits.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest pain
Chest discomfort or pain that may occur with activity or rest, often described as pressure, squeezing, or tightness in the chest.
Seek immediate emergency care if chest pain is severe, prolonged, or accompanied by shortness of breath, sweating, or pain radiating to the arm, jaw, or neck.
Sudden weakness or numbness
Sudden onset of weakness, numbness, or paralysis on one side of the body, often indicating a stroke.
This is a medical emergency. Call emergency services immediately if you experience sudden weakness, numbness, confusion, difficulty speaking, or loss of balance.
Shortness of breath
(cardiovascular)Difficulty breathing or feeling breathless, especially during physical activity or when lying flat.
Frequency: 50-60% of patients with heart involvement
Fatigue
(cardiovascular)Persistent tiredness or lack of energy that interferes with daily activities, often disproportionate to activity level.
Frequency: 40-50% of patients
Heart palpitations
(cardiovascular)Awareness of rapid, fluttering, or pounding heartbeats, sometimes felt in the chest or neck.
Frequency: 20-30% of patients
Leg pain when walking
(cardiovascular)Cramping, pain, or discomfort in the legs during walking or exercise that typically improves with rest (claudication).
Frequency: 15-25% of patients with peripheral artery disease
Swelling in legs
(cardiovascular)Fluid retention causing swelling (edema) in the lower legs, ankles, or feet.
Frequency: 20-30% of patients with heart involvement
Xanthomas
(cardiovascular)Yellowish deposits of fat under the skin, typically around tendons, caused by severely elevated lipid levels.
Frequency: Less than 5% of patients with genetic forms
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Cardiovascular risk stratification and monitoring
Comprehensive assessment of overall cardiovascular risk considering elevated lipoprotein(a) as an independent risk factor, with regular monitoring of disease progression and intervention response.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Aggressive cardiovascular risk factor management
Intensive control of all modifiable risk factors including blood pressure, smoking, and weight to compensate for elevated lipoprotein(a)-associated cardiovascular risk.
Additional treatment options
Lipoprotein(a)-lowering pharmacotherapy
Niacin or PCSK9 inhibitors may be considered to modestly reduce lipoprotein(a) concentrations, though response is variable and treatment focuses primarily on risk reduction.
medicationLipoprotein apheresis
Chronic LDL/Lp(a) apheresis for selected patients with very high lipoprotein(a) concentrations and established cardiovascular disease, providing mechanical removal of atherogenic particles.
procedureCardioprotective dietary pattern
Anti-inflammatory dietary approach rich in fruits, vegetables, whole grains, and omega-3 fatty acids to support overall vascular health despite persistent elevated lipoprotein(a) concentrations.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Lipoprotein A Concentration C5936894?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC Guideline on the Management of Blood Cholesterol. Circulation. 2019;139(25):e1082-e1143.
Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41(1):111-188.
Wilson DP, Jacobson TA, Jones PH, et al. Use of lipoprotein(a) in clinical practice: A biomarker whose time has come. A scientific statement from the National Lipid Association. J Clin Lipidol. 2022;16(4):e77-e95.
Kronenberg F, Mora S, Stroes ESG, et al. Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: A European Atherosclerosis Society consensus statement. Eur Heart J. 2022;43(39):3925-3946.
Emerging Risk Factors Collaboration, Di Angelantonio E, Gao P, et al. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA. 2009;302(4):412-423.
Tsimikas S, Fazio S, Ferdinand KC, et al. Recommendations for the management of elevated lipoprotein(a). J Am Coll Cardiol. 2020;75(24):2940-2957.
O'Donoghue ML, Fazio S, Giugliano RP, et al. Lipoprotein(a), PCSK9 inhibition, and cardiovascular risk. Circulation. 2019;139(12):1483-1492.
Braunwald E, Zipes DP, Libby P, Bonow RO, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Elsevier; 2019.
World Health Organization. Lipoprotein(a): WHO Information Sheet. Geneva: WHO; 2021.
Nordestgaard BG, Chapman MJ, Ray K, et al. Lipoprotein(a) as a cardiovascular risk factor: Current status. Eur Heart J. 2010;31(23):2844-2853.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Lipoprotein A Concentration C5936894. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy