Abnormal Circulating Lipoprotein Lipase Concentration C5539627
Lipoprotein lipase helps break down fats in the blood. Abnormal levels can cause fat buildup. Management includes dietary changes and sometimes specialized treatments.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Inflammation of the pancreas causing severe abdominal pain, nausea, and elevated pancreatic enzymes
Seek immediate medical attention for severe upper abdominal pain radiating to the back, especially with vomiting
Early-onset heart disease or atherosclerosis due to chronic lipid abnormalities
Seek immediate care for chest pain, shortness of breath, or symptoms of heart attack or stroke
Elevated blood triglyceride levels significantly exceeding normal limits, often exceeding 1000 mg/dL
(metabolic)Frequency: 90-95% of patients
Persistent or recurring pain in the abdominal region, often related to pancreatic involvement
(gastrointestinal)Frequency: 75-85% of patients
Small, yellow-red papules appearing on the skin, typically on the trunk, arms, and legs
(dermatologic)Frequency: 25-40% of patients
Ongoing tiredness and lack of energy that does not improve with rest
(constitutional)Frequency: 40-60% of patients
Enlargement of both the liver and spleen due to lipid accumulation
(gastrointestinal)Frequency: 15-25% of patients
Milky or creamy appearance of retinal blood vessels due to high lipid content in blood
(ocular)Frequency: 5-10% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Very low-fat dietary modification
Significant reduction in dietary fat intake to minimize substrate load for impaired lipoprotein lipase, helping manage abnormal circulating concentrations in patients with enzyme deficiency.
Fibrate therapy
Peroxisome proliferator-activated receptor agonists that may enhance residual lipoprotein lipase activity and improve triglyceride-rich lipoprotein metabolism in affected individuals.
Additional treatment options
Regular triglyceride and enzyme activity monitoring
Frequent laboratory assessment of circulating lipoprotein lipase concentrations and triglyceride levels to guide dietary compliance and therapeutic adjustments.
monitoringPlasmapheresis for severe cases
Therapeutic plasma exchange to rapidly reduce circulating triglyceride-rich lipoproteins in acute settings or when standard therapies fail to control concentrations.
procedureMedium-chain triglyceride oil supplementation
Use of MCT oils as an alternative fat source that bypasses lipoprotein lipase-dependent absorption, providing calories without exacerbating abnormal circulating concentrations.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Lipoprotein Lipase Concentration C5539627?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American Heart Association. 2018 AHA/ACC Guideline on the Management of Blood Cholesterol. Circulation. 2019;139:e1082–e1143.
European Atherosclerosis Society. 2019 ESC/EAS Guidelines for the management of dyslipidaemias. European Heart Journal. 2020;41:111-188.
Wang H, Eckel RH. Lipoprotein lipase: from gene to obesity. American Journal of Physiology-Endocrinology and Metabolism. 2009;297(2):E271-E288.
Gaudet D, Brisson D, Tremblay K, et al. Targeting lipoprotein lipase deficiency with gene therapy: results from a phase 1 trial. J Clin Invest. 2020;130(8):4185-4197.
Tremblay K, Méthot J, Brisson D, Gaudet D. Etiology and risk of hypertriglyceridemia. Curr Opin Lipidol. 2019;30(2):118-128.
Bates EJ, Groot E, Lee J, et al. Lipoprotein Lipase and Hepatic Lipase: Structure, Function and Regulation. In: Ridgway ND, McLeod RS, eds. Biochemistry of Lipids, Lipoproteins and Membranes. 7th ed. Elsevier; 2021:267-298.
Sarwar N, Danesh J, Eiriksdottir G, et al. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation. 2007;115(4):450-458.
National Lipid Association. Consensus statements on familial lipoprotein lipase deficiency. J Clin Lipidol. 2019;13(2):207-223.
Miller M, Stone NJ, Ballantyne C, et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2011;123(20):2292-2333.
Saxena U. Lipoprotein lipase and atherosclerosis: new insights into an old enzyme. Curr Opin Lipidol. 2018;29(4):282-287.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy