Abnormal Circulating Magnesium Concentration C4025274
A condition where magnesium levels in the blood are too high or too low. Magnesium is vital for muscles, nerves, and heart function. Treatment involves finding the cause and correcting levels through diet, supplements, or medications.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Sudden, uncontrolled electrical disturbances in the brain causing convulsions or loss of consciousness.
This is a medical emergency. Call emergency services immediately if a seizure occurs.
Difficulty Breathing
Shortness of breath or feeling like you cannot get enough air, potentially indicating respiratory depression.
Seek immediate emergency care for any breathing difficulty, especially if sudden or severe.
Muscle Twitching
(neurologic)Involuntary muscle contractions or twitches, often occurring in the hands, feet, or face.
Frequency: 70-80% of patients
Fatigue
(constitutional)Persistent tiredness, weakness, or lack of energy that interferes with daily activities.
Frequency: 60-70% of patients
Nausea and Vomiting
(gastrointestinal)Feeling of sickness with an urge to vomit, may occur with or without actual vomiting.
Frequency: 40-50% of patients
Irregular Heartbeat
(cardiovascular)Abnormal heart rhythm or palpitations that may feel like the heart is skipping beats or beating too fast.
Frequency: 30-40% of patients
Muscle Weakness
(neuromuscular)Reduced muscle strength making it difficult to perform everyday tasks or lift objects.
Frequency: 35-45% of patients
Drowsiness
(constitutional)Excessive sleepiness, lethargy, or difficulty staying awake during normal activities.
Frequency: 15-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Oral magnesium repletion
Magnesium salt supplementation (magnesium citrate, oxide, or glycinate) to correct deficiency and restore normal serum concentrations.
Magnesium-rich food increase
Increased consumption of magnesium-containing foods including leafy greens, nuts, seeds, and whole grains.
Additional treatment options
IV magnesium therapy
Intravenous magnesium administration for severe deficiency or symptomatic hypomagnesemia requiring rapid correction.
procedureSerum magnesium monitoring
Regular measurement of serum and optionally RBC magnesium to assess repletion status and guide therapy.
monitoringMedication review and optimization
Assessment and modification of medications that may be causing magnesium wasting, such as diuretics or proton pump inhibitors.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Magnesium Concentration C4025274?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
National Kidney Foundation. K/DOQI Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease. Am J Kidney Dis. 2003;42(4 Suppl 3):S1-S201.
Sutton RA, Domrongkitchaiboon S. Disorders of magnesium metabolism. In: Comprehensive Clinical Nephrology. 4th ed. Philadelphia: Elsevier; 2010:117-128.
Workgroup KD. KDIGO Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease. Kidney Int Suppl. 2018;8(3):91-165.
Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015;7(9):8199-8226.
Shapses SA, Driessen BCE. Electrolytes. In: Boron WF, Boulpaep EL, eds. Medical Physiology. 3rd ed. Philadelphia: Elsevier; 2017:1155-1178.
Perazella MA. Drug-induced renal failure: update on new medications and unique mechanisms of nephrotoxicity. Am J Med Sci. 2021;361(3):299-314.
Whang R, Whang DD, Ryan MP. Refractory potassium repletion: a consequence of magnesium deficiency. Arch Intern Med. 1992;152(1):40-45.
Alferez J, Schmuland E. Electrolyte disorders. In: Current Medical Diagnosis & Treatment 2023. New York: McGraw-Hill; 2023.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Magnesium Concentration C4025274. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy