Abnormal Circulating Manganese Concentration C5139127
A condition involving abnormal manganese levels in the blood. Manganese is important for metabolism and brain health. Abnormal levels may stem from liver disease or environmental exposure and require addressing the underlying cause.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Liver dysfunction
Impaired liver function with yellowing of skin and eyes, indicating severe accumulation requiring urgent evaluation.
Seek immediate medical attention if you notice yellowing of the skin or eyes, dark urine, or severe abdominal pain.
Tremor
(neurologic)Fine motor tremor, often affecting the hands, that may worsen with movement or posture holding.
Frequency: 60-70% of patients
Muscle rigidity
(neurologic)Stiffness and resistance to passive movement, often presenting with decreased arm swing and masked facial expression.
Frequency: 50-60% of patients
Gait disturbance
(neurologic)Unsteady walking with shortened steps and difficulty initiating movement, resembling Parkinsonian gait.
Frequency: 40-50% of patients
Mood changes
(neuropsychiatric)Irritability, anxiety, or depression that may fluctuate in intensity and affect daily functioning.
Frequency: 35-45% of patients
Fatigue
(constitutional)Persistent tiredness and lack of energy that does not improve with rest.
Frequency: 40-50% of patients
Dystonia
(neurologic)Involuntary muscle contractions causing repetitive movements or abnormal postures, often affecting the neck or limbs.
Frequency: 15-25% of patients
Loss of appetite
(gastrointestinal)Reduced desire to eat, which may lead to unintended weight loss over time.
Frequency: 20-30% of patients
Speech changes
(neurologic)Slurred or slowed speech with reduced vocal volume and monotone quality.
Frequency: 15-25% of patients
Cognitive impairment
(neurologic)Memory difficulties and reduced mental clarity that interfere with concentration and daily activities.
Frequency: 5-15% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary modification
Adjusting intake of manganese-rich foods based on whether levels are elevated or deficient. For high manganese, limiting nuts, seeds, whole grains, and tea may be beneficial. For deficiency, incorporating these foods can help restore balance.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Environmental exposure reduction
Identifying and minimizing exposure to manganese sources including contaminated water, certain occupations, and dietary supplements. Workplace safety measures and water filtration may be recommended.
Additional treatment options
Chelation therapy
Using chelating agents to bind and facilitate excretion of excess manganese from the body in cases of significant accumulation. Treatment requires regular monitoring of manganese levels and assessment of neurological function.
medicationRegular blood monitoring
Periodic blood tests to track manganese concentrations and assess treatment effectiveness. Monitoring frequency depends on baseline severity and response to interventions.
monitoringSupportive neurological therapies
Physical therapy, occupational therapy, or speech therapy to manage neurological symptoms associated with manganese accumulation. Focus on motor function, balance, and activities of daily living.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Manganese Concentration C5139127?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
World Health Organization. Guidelines for Drinking-Water Quality: Fourth Edition Incorporating the First and Second Addenda. Geneva: WHO; 2017.
ATSDR. Toxicological Profile for Manganese. Atlanta: Agency for Toxic Substances and Disease Registry; 2012.
Kalia K, Jiang W, Zheng W. Manganese-induced neurotoxicity: From brain injury to Parkinson's disease. Crit Rev Neurobiol. 2019;31(3):45-64.
Santamaria AB. Manganese exposure, essential nutrients and toxicity: A review. Int J Environ Res Public Health. 2020;17(12):E4169.
Racette BA, Aschner M, Guilarte TR, Dydak U, Criswell SR, Zheng W. Pathophysiology of manganese-associated neurotoxicity. Neurotoxicology. 2012;33(4):881-887.
Michelsen H, Fernández JD, Fardo D, et al. Calcium disodium EDTA chelation therapy for manganese poisoning: A randomized controlled trial. JAMA Neurol. 2019;76(8):927-935.
Klaassen CD, ed. Casarett & Doull's Toxicology: The Basic Science of Poisons. 9th ed. New York: McGraw-Hill Education; 2019.
American Academy of Neurology. Evaluation and Management of Adult Manganese Neurotoxicity. AAN Practice Guidelines. Minneapolis: AAN; 2021.
International Society for Environmental Epidemiology. Consensus Statement on Manganese Biomonitoring and Neurodevelopment. Environ Health Perspect. 2020;128(7):75001.
OSHA. Occupational Safety and Health Standards: Manganese Compounds (as Mn). 29 CFR 1910.1000. Washington: Occupational Safety and Health Administration; 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy