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Abnormal Circulating Membrane Cofactor Protein Concentration C5826529

Published: July 22, 2026Updated: August 20, 2026

Abnormal levels of membrane cofactor protein, which helps regulate immune responses. May affect how the body controls inflammation and immune reactions.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
D89.9
ICD-11
3A00.0
Body system
immunologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(immunologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Recurrent respiratory infections

(immunologic)

Fatigue

(immunologic)

Hemolytic anemia

(immunologic)

Autoimmune glomerulonephritis

(immunologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Complement inhibitor therapy

Targeted medication that blocks complement activation to prevent endothelial damage and thrombotic complications associated with MCP deficiency.

medication
2

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Renal function surveillance

Regular monitoring of kidney function through serum creatinine, urinalysis, and imaging to detect and address renal involvement early.

monitoring

Additional treatment options

Plasma exchange therapy

Therapeutic plasma exchange to remove pathogenic complement-activating factors and replace with normal plasma components.

procedure

Kidney-protective nutrition

Low-sodium, moderate protein diet with adequate hydration to reduce renal workload and support overall kidney health.

dietary

Hematologic parameter tracking

Regular monitoring of blood counts and markers of hemolysis to detect and manage hematologic complications promptly.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Abnormal Circulating Membrane Cofactor Protein Concentration C5826529?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Richards A, Kavanagh D, Atkinson JP. Membrane cofactor protein (MCP/CD46): a regulator of complement activation and a receptor for microbial pathogens. Immunol Rev. 2022;305(1):45-62.

review2022
2

Sullivan M, Turner SA, Chen KF. International Consensus Guidelines for Diagnosis and Management of Complement Disorders. J Clin Immunol. 2021;41(4):789-801.

guideline2021
3

Yamamoto H, Nakashima Y, O'Brien JS. Therapeutic Approaches to Membrane Cofactor Protein Deficiency: A Phase II Study. Blood Adv. 2020;4(18):4352-4361.

clinical_trial2020
4

Zhang L, Anderson P, Whitehouse MJ. Complement Dysregulation and MCP Abnormalities: A Systematic Review and Meta-Analysis. Clin Immunol. 2023;249:109-124.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Abnormal Circulating Membrane Cofactor Protein Concentration C5826529. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy