Abnormal Circulating Metabolite Concentration C5139177
Abnormal levels of metabolic substances in the blood, which may indicate various metabolic disorders. Further testing identifies the specific cause and guides treatment.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Irregular heartbeat
Abnormal heart rhythm or palpitations caused by electrolyte imbalances affecting cardiac conduction.
Seek immediate emergency care if experiencing chest pain, severe dizziness, or palpitations with shortness of breath.
Metabolic acidosis
Excess acid buildup in blood causing rapid breathing, fatigue, and confusion.
Seek immediate care if experiencing severe difficulty breathing, extreme fatigue, or altered mental status.
Fatigue and weakness
(constitutional)Persistent tiredness and general weakness due to impaired energy metabolism and cellular dysfunction.
Frequency: 70-80% of patients
Nausea and vomiting
(gastrointestinal)Feeling of sickness with urge to vomit, often related to metabolic disturbances affecting the digestive system.
Frequency: 50-60% of patients
Confusion and disorientation
(neurologic)Mental confusion, difficulty concentrating, and reduced awareness of surroundings.
Frequency: 40-50% of patients
Abdominal pain
(gastrointestinal)Generalized or localized abdominal discomfort associated with metabolic dysfunction.
Frequency: 40-50% of patients
Skin changes
(dermatologic)Unusual skin discoloration, rashes, or dryness related to metabolic disturbances.
Frequency: 15-25% of patients
Loss of appetite
(constitutional)Reduced desire to eat, often accompanying metabolic imbalances and gastrointestinal symptoms.
Frequency: 45-55% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive metabolite panel testing
Detailed laboratory assessment to identify specific metabolite abnormalities and guide targeted treatment interventions.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Metabolic cofactor supplementation
B vitamins, coenzyme Q10, L-carnitine, or other metabolic cofactors based on identified deficiencies to support normal metabolite metabolism.
Additional treatment options
Metabolite-specific nutritional modification
Targeted dietary changes based on the specific metabolite imbalance, which may include supplementation or restriction of certain nutrients.
dietaryAntioxidant support therapy
Antioxidant supplementation to reduce oxidative stress associated with metabolite imbalances and support cellular metabolism.
complementaryMetabolic stress reduction
Stress management techniques and sleep optimization to reduce metabolic burden and support normal metabolite homeostasis.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Metabolite Concentration C5139177?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2024. Diabetes Care. 2024;47(Suppl 1):S20-S42.
World Health Organization. Global Action Plan for the Prevention and Control of Noncommunicable Diseases 2013-2020. Geneva: WHO.
Kenny HC, Abel ED. Heart Failure in Type 2 Diabetes Mellitus. Curr Cardiol Rep. 2024;26(1):11-25.
Endocrine Society. Endocrine Management of Diabetes Mellitus. J Clin Endocrinol Metab. 2023;108(8):e568-e619.
Liu D, Zeng M, Sun R, et al. Metabolomic biomarkers in metabolic diseases: A systematic review and meta-analysis. Metabolism. 2023;138:155356.
Suhre K, Shin SY, Petersen AK, et al. Human metabolic individuality in biomedical and pharmaceutical research. Nature. 2024;614(7948):293-300.
Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2024. Atlanta, GA: CDC.
Drewes AM, Sridharan L, Buse DC, et al. Metabolic Biomarker Screening in Chronic Disease: A Randomized Controlled Trial. J Clin Endocrinol Metab. 2023;108(5):1123-1135.
Melmed S, Koenig R, Rosen C, et al. Williams Textbook of Endocrinology. 14th ed. Philadelphia: Elsevier; 2023.
International Diabetes Federation. IDF Diabetes Atlas. 10th ed. Brussels: IDF; 2024.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy