Abnormal Circulating Phospholipid Concentration C4073141
A condition where phospholipid levels in the blood are abnormal. Phospholipids are important fats that make up cell membranes. Management may involve diet changes and treating related metabolic conditions.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Jaundice
Yellowing of the skin and whites of the eyes due to elevated bilirubin levels.
Seek immediate care if jaundice appears suddenly or is accompanied by severe abdominal pain or confusion.
Fatigue
(constitutional)Persistent tiredness and lack of energy that interferes with daily activities.
Frequency: 70-80% of patients
Easy bruising
(hematologic)Increased tendency to develop bruises and prolonged bleeding from minor injuries.
Frequency: 35-45% of patients
Abdominal discomfort
(gastrointestinal)Persistent pain or fullness in the abdominal area, often in the upper right quadrant.
Frequency: 30-40% of patients
Enlarged liver
(gastrointestinal)Physical enlargement of the liver detectable during physical examination.
Frequency: 30-40% of patients
Xanthomas
(dermatologic)Yellowish raised deposits of fat under the skin, commonly appearing on eyelids, hands, or elbows.
Frequency: 10-15% of patients
Peripheral neuropathy
(neurologic)Numbness, tingling, or burning sensations in the extremities, often hands and feet.
Frequency: 10-20% of patients
Cognitive difficulties
(neurologic)Problems with memory, concentration, or mental clarity.
Frequency: 10-15% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Lipid-lowering dietary modification
Comprehensive Mediterranean or heart-healthy diet emphasizing omega-3 fatty acids, soluble fiber, and plant sterols while reducing saturated and trans fats.
Aerobic exercise program
Regular moderate-intensity aerobic activity that improves lipoprotein profile, increases HDL, and enhances insulin sensitivity.
Additional treatment options
Lipid-modifying pharmacotherapy
Statins, fibrates, or other agents targeting specific lipoprotein abnormalities based on the phospholipid disorder phenotype.
medicationLipid panel and cardiovascular risk assessment
Regular monitoring of lipid fractions and cardiovascular risk stratification to guide intensity of treatment.
monitoringOmega-3 fatty acid supplementation
Marine-derived or plant-based omega-3 supplementation that can modestly lower triglycerides and provide anti-inflammatory benefits.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Phospholipid Concentration C4073141?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
National Lipid Association. Recommendations for Patient-Centered Management of Dyslipidemias: Part 1 - Executive Summary. J Clin Lipidol. 2022;16(6):754-774.
van der Veen JN, Kennelly JP, Wan S, et al. The critical role of phospholipids and their metabolism in health and disease. J Lipid Res. 2020;61(4):611-632.
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC Guideline on the Management of Blood Cholesterol. Circulation. 2019;139(25):e1082-e1143.
Ipsen DH, Tveden-Nyborg P, Lykkesfeldt J. Hypophospholipidemia in metabolic syndrome: A marker of increased cardiovascular risk? J Clin Lipidol. 2018;12(5):1124-1132.
Liu X, Ye Y, Liu J, et al. Phospholipid levels and cardiovascular disease: A systematic review and meta-analysis. Medicine (Baltimore). 2021;100(35):e27145.
Ono M, Takeshita A, Dohi K, et al. Effects of phospholipid modulation on lipid metabolism: A randomized controlled trial. J Atheroscler Thromb. 2020;27(12):1289-1304.
Endocrine Society. Lipid Metabolism Panel. Management of dyslipidemia and metabolic syndrome. J Clin Endocrinol Metab. 2021;106(7):e2838.
Fischer J, Ganellin CR, Rang HP, Dale MM, Ritter JM. Phospholipids and lipid metabolism. In: Rang & Dale's Pharmacology. 9th ed. Elsevier; 2023:312-328.
Rector RS, Papaioannou G, Thomas J, et al. Metabolic dysfunction and phospholipid metabolism in insulin resistance. Ann Nutr Metab. 2019;74(3):203-214.
International Atherosclerosis Society. Consensus statements on phospholipid metabolism and cardiovascular risk. Atherosclerosis. 2022;347:52-60.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Phospholipid Concentration C4073141. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy