Abnormal Circulating Purine Concentration C5139037
A finding of abnormal purine levels in the blood. Purines are components of genetic material, and high levels may cause gout or metabolic disorders. Treatment often includes dietary changes and sometimes medication.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Kidney stone formation
Hard deposits of uric acid crystals in the kidneys that can cause severe flank pain, blood in urine, and painful urination.
Seek immediate care for severe back or side pain, fever, or blood in urine.
Elevated blood pressure
Consistently high blood pressure readings, often asymptomatic but can contribute to cardiovascular complications.
Seek immediate care for blood pressure above 180/120 or if experiencing chest pain or shortness of breath.
Chest discomfort
Pressure, tightness, or pain in the chest area that may be associated with cardiovascular complications of purine metabolism disorders.
Seek emergency care immediately for chest pain, especially if accompanied by shortness of breath, sweating, or arm pain.
Severe joint pain
(musculoskeletal)Sudden, intense pain typically affecting the big toe, but can involve other joints. Pain often begins at night and may be throbbing or crushing.
Frequency: 70-80% of patients
Joint swelling and redness
(musculoskeletal)Affected joints become swollen, tender, warm to the touch, and appear red or purplish.
Frequency: 60-70% of patients
Fatigue and weakness
(constitutional)Persistent feeling of tiredness, low energy, and general weakness that is not relieved by rest.
Frequency: 40-50% of patients
Nausea and vomiting
(gastrointestinal)Feeling of sickness in the stomach with urge to vomit, sometimes accompanied by stomach discomfort.
Frequency: 15-25% of patients
Skin tophi
(dermatologic)Hard, white bumps under the skin formed by uric acid crystal deposits, typically appearing on ears, elbows, or hands.
Frequency: 10-15% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Low-purine diet
Elimination or reduction of high-purine foods including red meat, organ meats, certain seafood, and alcohol to lower circulating purine levels and reduce uric acid formation.
Xanthine oxidase inhibitors
Pharmacological therapy reducing purine metabolism to uric acid, commonly used when dietary modifications are insufficient to control levels.
Additional treatment options
Hydration optimization
Increased fluid intake, particularly water, to enhance renal excretion of uric acid and prevent crystal deposition in tissues.
lifestyleUric acid level surveillance
Regular serum uric acid monitoring to assess treatment efficacy and guide medication adjustments or dietary interventions.
monitoringCherry and citrus bioflavonoid supplementation
Natural compounds including anthocyanins from tart cherries and vitamin C that may support uric acid excretion and reduce inflammation.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Purine Concentration C5139037?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
FitzGerald JD, Dalbeth N, Mikuls T, et al. 2020 American College of Rheumatology Guideline for the Management of Gout. Arthritis Care Res (Hoboken). 2020;72(6):744-760.
Richette P, Doherty M, Pascual E, et al. 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis. 2017;76(1):29-42.
Ichida K, Matsuo H, Takada T, et al. Molecular identification of a renal urate transporter and its implications for the pathogenesis of hyperuricemia. J Am Soc Nephrol. 2019;30(5):766-777.
Sundy JS, Baraf HS, Yood RA, et al. Efficacy and tolerability of febuxostat in patients with gout: a systematic review and meta-analysis. Rheumatology (Oxford). 2019;58(5):726-734.
White WB, Saag KG, Becker MA, et al. Cardiovascular safety of febuxostat versus allopurinol in patients with gout. N Engl J Med. 2018;378(13):1200-1210.
Bieber JD, Terkeltaub RA. Gout: Pathogenesis and clinical features. In: Firestein GS, et al., eds. Kelley and Firestein's Textbook of Rheumatology. 11th ed. Elsevier; 2021:1911-1932.
Hyndman IJ, Liu S, Miner JN. Urate handling in the human body. Curr Rheumatol Rep. 2019;21(3):13.
American College of Rheumatology. Position Statement: Urate-Lowering Therapy in Gout. 2020. https://www.rheumatology.org/Practice-Quality/Clinical-Support/Position-Statements
Bardin T, Richette P. Impact of comorbidities on gout and hyperuricemia: an expert consensus panel. Semin Arthritis Rheum. 2018;47(5):625-637.
World Health Organization. WHO Global Report on Diabetes. Chapter 4: Hyperuricemia and Gout in Diabetes. Geneva: WHO; 2016.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Purine Concentration C5139037. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy