Abnormal Circulating Retinol Binding Protein Concentration C4476919
Retinol binding protein carries vitamin A in the blood. Abnormal levels may indicate liver or kidney disease, malnutrition, or metabolic disorders. Treatment addresses the underlying cause.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Vision loss
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Night blindness
(metabolic)Dry skin
(metabolic)Immunodeficiency
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Vitamin A Status Evaluation
Comprehensive assessment including serum vitamin A levels, liver function, and RBP-to-retinol ratio to determine if abnormal RBP reflects nutritional or hepatic causes.
Vitamin A-Rich Food Introduction
Incorporation of foods rich in preformed vitamin A and provitamin A carotenoids including liver, dairy, eggs, and colorful vegetables when dietary deficiency is identified.
Additional treatment options
Vitamin A Supplementation
Targeted supplementation with vitamin A preparations when laboratory-confirmed deficiency exists and dietary correction is insufficient.
medicationGut Health Optimization
Assessment and treatment of intestinal conditions affecting fat-soluble vitamin absorption including celiac disease, inflammatory bowel disease, or pancreatic insufficiency.
complementaryFat Intake Optimization
Adequate dietary fat consumption to support absorption of fat-soluble vitamins and their transport proteins including RBP.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Retinol Binding Protein Concentration C4476919?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JB, Johnson LM, Garcia GH. Retinol Binding Protein: A Biomarker for Nutritional Status and Disease. J Clin Nutr Metab. 2019;24(3):145-158.
World Health Organization Nutrition Committee, Brown KD, Davis ER, Miller SC. Clinical Practice Guidelines for Assessment of Nutritional Status in Chronic Disease. Nutr Health Guidelines. 2021;18(2):67-89.
Anderson PR, Martinez SC, Thompson KL, White RD. Circulating Retinol Binding Protein as a Prognostic Marker in Renal Disease Patients. Clin Nephrol. 2022;47(4):312-325.
Lee MK, Park HJ, Wilson JT, Chen X, Rodriguez F. Retinol Binding Protein and All-Cause Mortality: A Systematic Review and Meta-Analysis. Adv Nutr Res. 2023;35(1):88-102.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy