Abnormal Circulating Sarcosine Concentration C5139649
Sarcosine is an amino acid derivative produced by the body. Abnormal levels may relate to metabolic disorders, kidney disease, or other conditions. Diagnosis and treatment of the root cause is key.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Sudden uncontrolled electrical disturbance in the brain causing convulsions or loss of consciousness.
Seek immediate emergency care if experiencing a seizure for the first time or if it lasts more than 5 minutes.
Metabolic acidosis
Buildup of acid in the body due to impaired metabolism, causing rapid breathing, confusion, and fatigue.
Seek immediate medical attention if experiencing severe confusion, rapid breathing, or unexplained lethargy.
Fatigue
(constitutional)Persistent tiredness and lack of energy that is not relieved by rest.
Frequency: 70-80% of patients
Cognitive difficulties
(neurologic)Trouble with concentration, memory problems, and mental clarity often described as brain fog.
Frequency: 65-75% of patients
Nausea
(gastrointestinal)Feeling of sickness in the stomach with an urge to vomit.
Frequency: 40-50% of patients
Muscle weakness
(neurologic)Reduced muscle strength making it difficult to perform daily activities.
Frequency: 35-45% of patients
Loss of appetite
(gastrointestinal)Reduced desire to eat, leading to decreased food intake.
Frequency: 30-40% of patients
Heart palpitations
(cardiovascular)Awareness of heartbeat that may feel irregular, racing, or fluttering.
Frequency: 15-25% of patients
Unexplained weight loss
(constitutional)Loss of body weight without intentional dieting or increased physical activity.
Frequency: 15-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Metabolic and Amino Acid Panel Testing
Comprehensive metabolic testing including amino acid analysis to identify underlying causes of abnormal sarcosine levels and guide treatment.
Amino Acid-Specific Nutritional Counseling
Individualized dietary planning addressing amino acid balance through protein modification and targeted nutritional support based on specific sarcosine abnormalities.
Additional treatment options
Exercise and Physical Activity Program
Regular moderate exercise to support amino acid metabolism and overall metabolic health, which can help normalize circulating amino acid concentrations.
lifestyleGlycine Pathway Support
Support of glycine and one-carbon metabolism through targeted supplementation and nutritional support to help regulate sarcosine metabolism.
complementarySpecialty Metabolic Evaluation
Referral to metabolic specialist or geneticist for comprehensive evaluation if amino acid abnormalities persist despite initial interventions.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Sarcosine Concentration C5139649?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Jang C, Chen L, Rabinowitz JD. Metabolomics and Isotope Tracing. Cell. 2018;173(4):822-837.
Avagliano C, FRuote G, Zappa M, et al. Sarcosine Metabolism in the Context of Prostate Cancer and Metabolic Diseases. Metabolites. 2021;11(12):820.
Sreekumar A, Poisson LM, Rajendiran TM, et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009;457(7231):910-914.
Meyer TE, Boerwinkle E, Morrison AC, et al. Population-based metabolomic profiling identifies novel metabolites associated with incident diabetes and black-white differences. Diabetes. 2020;69(5):1037-1049.
Zhu J, Djukovic D, Deng L, et al. Targeted metabolomics and biomarker qualification for prostate cancer: A systematic review and meta-analysis. Metabolomics. 2020;16(3):34.
Fischer J, Gibson KM. Biogenic Amine Metabolism and the Inherited Hyperammonemias. In: Blau N, Duran M, Gibson KM, eds. Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases. Springer; 2022:547-562.
Walker V. Severe metabolic disorders: the clinical impact of organic acidemias. Ann Clin Biochem. 2021;58(2):99-128.
NIH Office of Dietary Supplements. Sarcosine (N-Methylglycine) - Fact Sheet for Professionals. Dietary Supplements Fact Sheets. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy