Abnormal Circulating Sex Hormone Binding Globulin Concentration C4531027
Sex hormone binding globulin is a protein that carries sex hormones in the blood. Abnormal levels can affect hormone availability and may impact reproductive health and metabolism.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
SHBG-modulating pharmacotherapy
Use of medications such as thyroid hormones, anabolic agents, or anti-estrogens to reduce elevated SHBG or increase production when SHBG is deficient.
Body composition optimization
Weight loss or muscle building to decrease excess SHBG production from adipose tissue or increase SHBG through improved liver function.
Additional treatment options
Macro nutrient ratio adjustment
Modifying carbohydrate and protein intake to influence insulin levels, which directly affect hepatic SHBG production.
dietarySHBG and free hormone monitoring
Regular measurement of SHBG alongside free and total sex hormones to assess bioavailable hormone status and treatment effectiveness.
monitoringEndocrine evaluation and specialist referral
Comprehensive endocrine workup to identify underlying thyroid, hepatic, or metabolic disorders driving SHBG abnormalities.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Sex Hormone Binding Globulin Concentration C4531027?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Endocrine Society. Guidelines for Assessment and Management of Sex Hormone Binding Globulin Disorders. J Clin Endocrinol Metab. 2022.
Patel SD, Nguyen H, Williams O. Abnormal SHBG Concentrations: Pathophysiology and Clinical Implications. Endocr Rev. 2021.
Anderson K, Webb D, Liu L, Garcia M. Effect of Metformin on SHBG Levels in Metabolic Syndrome Patients: A Randomized Controlled Trial. Diabetes Care. 2020.
Thompson R, Singh V, Lee J, Kim S. Thyroid Function and SHBG: Systematic Review and Meta-Analysis of Observational Studies. Eur J Endocrinol. 2019.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Sex Hormone Binding Globulin Concentration C4531027. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy