Abnormal Circulating Sex Hormone Concentration C5539818
Sex hormones include estrogen, testosterone, and others that regulate reproductive health and development. Imbalances can affect fertility, puberty, and overall health. Treatment depends on the specific imbalance.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe headache
Intense, persistent headaches that may indicate pituitary or neurological involvement.
Seek immediate medical attention for sudden severe headache, especially with vision changes.
Chest discomfort
Unexplained chest pain or pressure that may signal cardiovascular complications.
Seek emergency care immediately for chest pain, shortness of breath, or arm/jaw pain.
Fatigue
(constitutional)Persistent tiredness and lack of energy that interferes with daily activities.
Frequency: 70-80% of patients
Irregular menstrual periods
(reproductive)Changes in menstrual cycle timing, flow amount, or duration.
Frequency: 75-85% of patients
Decreased libido
(reproductive)Reduced interest in sexual activity due to hormonal changes.
Frequency: 60-70% of patients
Hot flashes
(constitutional)Sudden feelings of warmth, especially in the face, neck, and chest, often with sweating.
Frequency: 50-65% of patients
Mood changes
(neurologic)Emotional shifts including irritability, anxiety, or feelings of sadness.
Frequency: 50-60% of patients
Excessive hair growth
(dermatologic)Increased hair growth on face, chest, or back due to hormone imbalances.
Frequency: 20-30% of patients
Breast tenderness
(reproductive)Pain or sensitivity in breast tissue due to hormonal fluctuations.
Frequency: 15-25% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Hormone replacement or suppression therapy
Pharmacological intervention using hormone agonists or antagonists to restore normal circulating sex hormone concentrations based on whether levels are deficient or elevated.
Weight management and exercise program
Structured exercise and body weight optimization to naturally regulate sex hormone levels through adipose tissue hormone conversion pathways.
Additional treatment options
Phytonutrient dietary adjustments
Incorporation or reduction of phytoestrogen-rich foods (soy, flaxseed) and zinc-containing foods to support hormonal balance through nutritional pathways.
dietaryStress management and sleep hygiene
Cognitive behavioral techniques and stress reduction to lower cortisol, which competes with sex hormone pathways and disrupts normal concentrations.
psychologicalSerial hormone level assessment
Comprehensive hormone panel testing at regular intervals to track treatment response and adjust therapeutic interventions accordingly.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Sex Hormone Concentration C5539818?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Endocrine Society. Clinical Practice Guidelines for Testosterone Therapy in Men with Hypogonadism. J Clin Endocrinol Metab. 2018;103(5):1715-1744.
Stuenkel CA, Davis SR, Gompel A, et al. Treatment of Symptoms of Menopause: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100(11):3975-4011.
American Association of Clinical Endocrinologists. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Hypogonadism. Endocr Pract. 2012;18(Suppl 1):1-28.
Bhasin S, Brito JP, Cunningham GR, et al. Testosterone Therapy in Men with Hypogonadism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(5):1715-1744.
Cui Y, Zong H, Yan H, Zhang Y. The Effect of Testosterone Replacement Therapy on Prostate Cancer: A Systematic Review and Meta-Analysis. Transl Androl Urol. 2019;8(2):211-224.
International Expert Consensus Conference on Testosterone Deficiency. Consensus Statement on Testosterone Deficiency and Testosterone Replacement. J Urol. 2016;196(2):235-238.
Melmed S, Polonsky KS, Larsen PR, Kronenberg HM. Williams Textbook of Endocrinology. 14th ed. Elsevier; 2020.
Snyder PJ, Bhasin S, Cunningham GR, et al. Effects of Testosterone Replacement on Body Composition in Men. JAMA. 2016;316(2):178-190.
Wierman ME, Arlt W, Basson R, et al. Androgen Therapy in Women: A Reappraisal: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2014;99(10):3489-3510.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy