Abnormal Circulating Threonine Concentration C4023666
This refers to abnormal levels of threonine, an amino acid used in protein building. It can result from genetic factors or nutritional issues and is typically addressed through dietary adjustments.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Confusion
Mental clouding or difficulty thinking clearly and coherently.
Immediately seek care if confusion is sudden, severe, or accompanied by other concerning symptoms
Severe lethargy
Extreme tiredness and unresponsiveness that may indicate metabolic stress.
Immediately seek emergency care if lethargy is severe or patient cannot be awakened
Fatigue
(constitutional)Persistent tiredness and lack of energy that interferes with daily activities.
Frequency: 70-80% of patients
Loss of appetite
(gastrointestinal)Reduced desire to eat, leading to decreased food intake.
Frequency: 50-60% of patients
Nausea
(gastrointestinal)Feeling of wanting to vomit, which may or may not be accompanied by actual vomiting.
Frequency: 40-50% of patients
Poor growth in children
(constitutional)Inadequate weight gain and height growth in pediatric patients.
Frequency: 40-50% of children
Difficulty concentrating
(neurologic)Trouble focusing attention or maintaining mental focus on tasks.
Frequency: 20-30% of patients
Skin rash
(dermatologic)Localized or generalized skin irritation presenting as red or itchy patches.
Frequency: 15-20% of patients
Mild hypotension
(cardiovascular)Slightly lowered blood pressure that may cause brief dizziness upon standing.
Frequency: 10-15% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Threonine dietary assessment and modification
Evaluation of dietary threonine intake through comprehensive nutritional analysis with adjustment of protein sources to achieve balanced amino acid consumption.
Additional treatment options
Serial amino acid panel monitoring
Regular laboratory monitoring of threonine and other essential amino acid levels to assess treatment efficacy and guide dietary adjustments.
monitoringMedical nutrition therapy
Individualized meal planning with a registered dietitian specializing in metabolic disorders to ensure optimal amino acid balance.
dietaryDietary counseling support
Behavioral and psychological support to help patients maintain dietary modifications long-term and address any eating relationship concerns.
psychologicalGut microbiome evaluation
Assessment of intestinal flora which can influence amino acid metabolism and absorption patterns.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Threonine Concentration C4023666?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Rossi A, et al. Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Hereditary Metabolic Diseases. Springer. 2020.
Saudubray JM, et al. Inborn Metabolic Diseases: Diagnosis and Treatment. Springer Nature. 2022.
American College of Medical Genetics and Genomics. Clinical Utility of Genetic Testing for Amino Acid Metabolism Disorders. Genet Med. 2021.
Society for Inherited Metabolic Disorders. Guidelines for the Management of Amino Acid Metabolism Disorders. J Inherit Metab Dis. 2019.
Blau N, et al. Physician's Guide to the Management of PKU. Springer. 2018.
Heringer J, et al. Effects of Dietary Treatment on Amino Acid Disorders: A Systematic Review and Meta-Analysis. Mol Genet Metab. 2020.
van Spronsen FJ, et al. Nutritional Management of Amino Acid Metabolism Disorders: A Multicenter Study. Orphanet J Rare Dis. 2021.
Camp KM, et al. Expanding the Newborn Screening Recommendations to Include Amino Acid Disorders. Pediatrics. 2022.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Threonine Concentration C4023666. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy