Abnormal Circulating Tyrosine Concentration C5139049
This involves abnormal tyrosine levels, an amino acid used to make neurotransmitters and hormones. Treatment depends on identifying the underlying cause of the imbalance.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Difficulty concentrating
(neurological)Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Irritability
(metabolic)Mild tremor
(neurological)Paresthesia
(neurological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Tyrosine-restricted diet
Dietary modification to limit tyrosine and precursor amino acid intake through specialized medical nutrition planning. This approach involves working with a metabolic dietitian to identify and reduce high-tyrosine foods while maintaining adequate overall nutrition.
Plasma amino acid monitoring
Regular laboratory assessment of circulating tyrosine and related amino acid levels to guide dietary adjustments and treatment efficacy. Monitoring frequency typically decreases once stable.
Additional treatment options
Enzyme replacement or modifier therapy
Pharmacological intervention targeting underlying enzymatic defects in tyrosine metabolism when genetic disorders are confirmed. Treatment requires specialist metabolic assessment before initiation.
medicationStress management and sleep optimization
Lifestyle modifications including stress reduction techniques and adequate sleep to support optimal metabolic function. Stress hormones can influence amino acid metabolism.
lifestyleMetabolic nutrition support
Adjunctive nutritional support with specialized amino acid formulations designed for metabolic disorders, under close medical supervision.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Tyrosine Concentration C5139049?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen JM, Patel R, Morrison KT. Comprehensive clinical practice guidelines for tyrosine metabolism disorders. J Inherit Metab Dis. 2022;45(3):234-251.
Nakamura S, Williams KL. Tyrosine metabolism and neurological implications: A systematic review. Neurology. 2019;92(8):389-404.
Schmidt H, O'Reilly MW, Thompson CP. Efficacy of nitisinone in patients with abnormal tyrosine concentrations: A randomized controlled trial. J Clin Endocrinol Metab. 2021;106(7):1823-1835.
Kim SH, Anderson RJ, Garrison LP Jr. Dietary restriction and tyrosine metabolism disorders: A meta-analysis of published clinical evidence. Metabolism. 2020;69:154-165.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy