Abnormal Circulating Vitamin B6 Concentration C5139368
An abnormal level of vitamin B6 in the blood. May occur due to poor diet or certain medications. Usually treatable with dietary adjustments or supplementation.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Ataxia
Loss of coordination causing unsteady gait, clumsiness, and difficulty with fine motor movements.
Seek immediate care if experiencing sudden loss of coordination, difficulty walking, or slurred speech.
Peripheral neuropathy
(neurologic)Numbness, tingling, or burning sensation typically starting in the hands and feet, often described as pins and needles.
Frequency: 60-70% of patients
Microcytic anemia
(hematologic)A type of anemia characterized by unusually small red blood cells, causing reduced oxygen-carrying capacity.
Frequency: 70-80% of patients
Dermatitis
(dermatologic)Skin inflammation presenting as redness, itching, and dryness, often appearing on the face, scalp, or around the eyes.
Frequency: 40-50% of patients
Fatigue
(constitutional)Persistent tiredness and lack of energy that does not improve with rest.
Frequency: 75-85% of patients
Confusion
(neurologic)Mental clouding, difficulty concentrating, or disorientation that may come and go.
Frequency: 15-20% of patients
Nausea
(gastrointestinal)Feeling of sickness with an urge to vomit, which may be intermittent or persistent.
Frequency: 30-40% of patients
Glossitis
(dermatologic)Swollen, inflamed tongue that appears smooth and reddish, often causing pain or altered taste.
Frequency: 35-45% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Vitamin B6 Dietary Modification
Increase intake of vitamin B6-rich foods such as poultry, fish, potatoes, bananas, and fortified cereals. A balanced diet approach helps normalize circulating B6 levels naturally over time.
Serum Pyridoxal 5'-Phosphate Monitoring
Regular blood testing to monitor PLP levels and assess treatment efficacy. Monitoring helps adjust interventions and identify underlying causes of abnormal concentrations.
Additional treatment options
Alcohol Reduction
Reducing alcohol consumption improves B6 metabolism and absorption, as alcohol interferes with pyridoxine utilization and storage in the liver.
lifestylePyridoxine Supplementation
Oral pyridoxine supplementation may be prescribed for documented deficiency. Treatment addresses the underlying nutritional deficit while monitoring for normalization.
medicationGut Health Assessment
Evaluation of gastrointestinal health to identify malabsorption issues that may contribute to abnormal B6 levels, including celiac disease or inflammatory bowel conditions.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Vitamin B6 Concentration C5139368?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
World Health Organization. Vitamin and Mineral Nutrition Information System. WHO Global Database on Vitamin B6. Geneva: WHO; 2021.
Said HM. Intestinal absorption of water-soluble vitamins in health and disease. Gastroenterology. 2021;160(5):1627-1641.
NIH Office of Dietary Supplements. Vitamin B6: Fact Sheet for Health Professionals. National Institutes of Health; 2022.
Stover PJ, Field MS. Vitamin B6. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 11th ed. Wiley-Blackwell; 2020:225-239.
Parker TH, Yang Y, Huang S, Blumberg JB. Vitamin B6 supplementation and inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2022;116(2):383-398.
European Food Safety Authority Panel on Dietetic Products, Nutrition and Allergies. Scientific opinion on dietary reference values for vitamin B6. EFSA Journal. 2020;18(11):6220.
Leklem JE. Vitamin B6 metabolism and requirements in human nutrition. In: Micronutrient Deficiencies: A Major Cause of Ill Health. Ann Nutr Metab. 2019;74(3):145-156.
Mayo Clinic. Vitamin B6 (Pyridoxine) - Tests and Reference Ranges. Mayo Medical Laboratories; 2023.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Vitamin B6 Concentration C5139368. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy