Abnormal Circulating Vitamin K Concentration C4021958
Abnormal vitamin K affects blood clotting and bone health. It can result from malabsorption, liver disease, or prolonged antibiotic use. Treatment includes supplementation.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Gastrointestinal bleeding
Presence of blood in stool (melena or hematochezia) or vomit indicating internal bleeding.
This is a medical emergency. Seek immediate care if you notice black/tarry stools or blood in vomit.
Intracranial hemorrhage
Life-threatening bleeding within the skull that can cause sudden neurological deficits.
This is a medical emergency. Call emergency services immediately for sudden severe headache, vision changes, weakness, or loss of consciousness.
Easy bruising
(hematologic)Development of bruises or purpura on the skin with minimal trauma due to impaired blood clotting.
Frequency: 60-70% of patients
Gum bleeding
(gastrointestinal)Bleeding from the gums, especially during brushing or eating, due to insufficient clotting factors.
Frequency: 40-50% of patients
Nosebleeds
(respiratory)Recurrent or prolonged nosebleeds (epistaxis) occurring spontaneously or with minor irritation.
Frequency: 30-40% of patients
Prolonged bleeding from cuts
(hematologic)Extended bleeding time from minor cuts or wounds that takes longer than normal to stop.
Frequency: 50-60% of patients
Bone pain or fractures
(musculoskeletal)Increased bone fragility and pain due to impaired osteocalcin function in bone metabolism.
Frequency: 10-15% of patients
Unexplained fatigue
(constitutional)Generalized tiredness and weakness that may be related to chronic blood loss or anemia.
Frequency: 35-45% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Vitamin K-rich dietary changes
Increased consumption of vitamin K sources including leafy green vegetables, broccoli, and fermented foods to address deficiency. Treatment approach supports normal coagulation factor synthesis and bone metabolism.
Vitamin K supplementation
Phylloquinone or menaquinone supplementation to correct deficiency and normalize clotting factor function. Treatment approach involves oral or injectable administration based on severity.
Additional treatment options
Coagulation factor assessment
Prothrombin time and INR monitoring to evaluate clotting factor status during treatment. Treatment approach ensures adequate response to vitamin K therapy.
monitoringMedication review and adjustment
Systematic review of medications that may interfere with vitamin K metabolism or anticoagulant therapy. Treatment approach minimizes drug interactions affecting vitamin K status.
procedureGut health optimization
Support for intestinal bacteria that produce vitamin K through probiotic supplementation and gut health measures. Treatment approach enhances endogenous vitamin K synthesis.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Vitamin K Concentration C4021958?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American Academy of Pediatrics. Prevention of Vitamin K Deficiency Bleeding in Newborns. Pediatrics. 2003;112(1 Pt 1):191-192.
Shearer MJ, Newman P. Metabolism and cell biology of vitamin K. Thromb Haemost. 2014;112(4):761-771.
Walther B, Karleng J, Mete A, et al. Vitamin K and bone health: a review on the effects of vitamin K deficiency and supplementation and disease states. Eur J Clin Nutr. 2018;72(12):1617-1629.
Khan SU, Khan MU, Riaz H, et al. Effects of Vitamin K Supplementation on Vascular Health: A Systematic Review and Meta-Analysis. J Am Coll Cardiol. 2019;73(10):1190-1198.
Fusaro M, Noale M, Vitiello V, et al. Vitamin K and bone metabolism: a review of the literature. J Nephrol. 2012;25(5):617-631.
Schurgers LJ, Shearer MJ, Hamulyák K, et al. Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects. Blood. 2004;104(9):2682-2689.
World Health Organization. Guidelines for the Management of Traumatic Bleeding. Geneva: WHO; 2011.
Hoffbrand AV, Moss PAH. Essential Haematology. 7th ed. Chichester: Wiley-Blackwell; 2016.
Expert Working Group on Vitamin K. Vitamin K deficiency: a position statement. J Pediatr Gastroenterol Nutr. 2008;47(2):160-167.
Nowak JK, Grzybowska-Chlebowczyk U. Assessment of vitamin K status in clinical practice. Rocz Panstw Zakl Hig. 2020;71(3):277-285.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy