Abnormal Cortical Peritubular Capillary Lumen Morphology C5558253
A structural abnormality of the inner space of small blood vessels surrounding kidney tubules. May affect kidney function. Management depends on the specific condition.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Oliguria
Reduced urine output indicating impaired kidney function and filtration.
Seek immediate medical attention if urine output drops significantly or stops completely.
Hematuria
(renal)Presence of blood in the urine, which may appear pink, red, or brown.
Frequency: 70-80% of patients
Proteinuria
(renal)Excess protein in the urine, often causing foamy or frothy appearance.
Frequency: 65-75% of patients
Hypertension
(cardiovascular)Elevated blood pressure due to impaired kidney function and fluid regulation.
Frequency: 50-60% of patients
Peripheral Edema
(cardiovascular)Swelling in the legs, ankles, feet, or hands due to fluid retention from reduced kidney function.
Frequency: 40-50% of patients
Fatigue
(constitutional)Persistent tiredness and weakness due to anemia and buildup of waste products in the blood.
Frequency: 45-55% of patients
Flank Pain
(renal)Pain in the side or back below the ribs, often indicating kidney involvement or inflammation.
Frequency: 20-30% of patients
Foamy Urine
(renal)Urine that appears frothy or bubbly due to high levels of protein.
Frequency: 35-45% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Renal function surveillance
Regular monitoring of kidney function including serum creatinine, GFR, urinalysis, and blood pressure to assess functional impact of peritubular capillary abnormalities.
Blood pressure optimization
Antihypertensive therapy to maintain optimal renal perfusion pressure and reduce further microvascular damage to cortical structures.
Additional treatment options
Renal-protective nutrition
Dietary modifications including controlled protein intake, sodium restriction, and potassium management tailored to preserve remaining renal function.
dietaryVascular risk factor modification
Smoking cessation, weight management, and glycemic control in diabetic patients to reduce ongoing microvascular injury to kidney structures.
lifestyleRenal biopsy assessment
Diagnostic biopsy to characterize the nature and severity of capillary pathology and guide prognosis and treatment decisions.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Cortical Peritubular Capillary Lumen Morphology C5558253?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Heinz L. Walker, Jennie H. Kwon. Renal Pathology. In: Brenner and Rector's The Kidney. 11th ed. Elsevier; 2019.
Siddigi E, Mehrdad M, Seshan SV. Peritubular Capillary Changes in Renal Allograft Dysfunction. Clin J Am Soc Nephrol. 2020;15(10):1520-1532.
Racusen LC, Solez K, Colvin RB, et al. The Banff 97 Working Classification of Renal Allograft Pathology. Kidney Int. 1999;55(2):713-723.
Brown K, Moin B, Bomback AS, et al. Histopathological Classification of Chronic Kidney Disease. Kidney Int Rep. 2021;6(5):1354-1364.
Perazella MA, Moeckel GW. Pathophysiology of Drug-Induced Renal Injury. Clin J Am Soc Nephrol. 2010;5(12):2162-2172.
Fogo AB. Approach to Renal Biopsy. Am J Kidney Dis. 2020;75(4):599-614.
Seron D, Cohen AH, Hogg R, et al. Consensus on Renal Biopsy Pathology. Kidney Int. 2019;96(2):287-299.
Matsushita K, Ballew SH, Astor BC, et al. Chronic Kidney Disease Prognosis Consortium: Meta-Analysis of Glomerular Filtration Rate and Albuminuria. Kidney Int. 2019;96(2):317-329.
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl. 2012;3(1):1-150.
Jensen ME, O'Neill PV, Moghaddam S, et al. Microvascular Renal Disease: Histopathology and Clinical Correlations. Pathology. 2021;53(4):451-462.
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy