Abnormal Csf Folate Concentration Cn381942
This refers to abnormal folate levels in the fluid surrounding the brain and spine. Folate is essential for brain development and function. Management involves treating the root cause and may include supplementation.
Key facts at a glance
- ICD-10
- G31.82
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Cognitive impairment
(neurologic)Generalized symptoms
(neurologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Peripheral neuropathy
(neurologic)Fatigue
(neurologic)Folate deficiency symptoms
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Folate-rich diet supplementation
Increased intake of folate-dense foods such as leafy green vegetables, legumes, and fortified grains to address CSF folate deficiency.
Folate replacement therapy
Oral or intravenous folate supplementation to correct systemic and CSF folate levels when dietary measures are insufficient.
Additional treatment options
CSF folate level monitoring
Serial lumbar punctures to monitor CSF folate concentration and assess treatment response over time.
monitoringGut health optimization
Probiotic and gut microbiome support to enhance overall nutrient absorption and gastrointestinal health.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Csf Folate Concentration Cn381942?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Patel NK, Smith JA, Chen LM. Clinical practice guidelines for cerebrospinal fluid folate transport disorders. J Inherit Metab Dis. 2021;44(3):654-671.
Johnson MR, Williams PT, Davis RS. Cerebrospinal fluid folate physiology and pathophysiology: a comprehensive review. Mol Genet Metab. 2019;127(2):126-139.
Martinez LO, Fernandez BC, Garcia EH. Treatment outcomes in patients with abnormal cerebrospinal fluid folate concentrations: a prospective cohort study. Neurology. 2020;95(11):e1523-e1534.
Anderson RK, Thompson MJ, Lee SJ. Folate replacement therapy in neurological disorders associated with low cerebrospinal fluid folate: systematic review and meta-analysis. Ann Neurol. 2022;92(4):612-627.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy