Abnormal Csf Glutamine Concentration C5139581
This involves abnormal glutamine levels in the fluid around the brain and spine. Glutamine supports brain metabolism and helps remove harmful ammonia. Imbalances may indicate liver or neurological issues. Treatment targets the root cause.
Key facts at a glance
- ICD-10
- G31.82
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Sudden, uncontrolled electrical disturbance in the brain causing convulsions or loss of consciousness.
Seek immediate medical attention if experiencing a seizure for the first time or if seizures last more than 5 minutes.
Coma
State of deep unconsciousness from which a person cannot be aroused.
This is a medical emergency. Call emergency services immediately.
Mental confusion
(neurologic)Difficulty thinking clearly, concentrating, or maintaining awareness of surroundings.
Frequency: 80-90% of patients
Fatigue
(constitutional)Persistent tiredness, weakness, and lack of energy that interferes with daily activities.
Frequency: 70-85% of patients
Nausea
(gastrointestinal)Feeling of sickness in the stomach with urge to vomit.
Frequency: 50-65% of patients
Headache
(neurologic)Persistent or recurrent pain in the head region, often described as dull or pressure-like.
Frequency: 40-55% of patients
Disorientation
(neurologic)Confusion about time, place, or identity; difficulty recognizing familiar people or locations.
Frequency: 35-50% of patients
Asterixis
(neurologic)Brief loss of muscle tone causing involuntary jerking movements, often noticed when holding arms outstretched.
Frequency: 30-45% of patients
Ataxia
(neurologic)Loss of coordination and balance, resulting in unsteady gait and clumsiness.
Frequency: 15-25% of patients
Personality changes
(neurologic)Alterations in behavior, mood, or social conduct that differ from usual patterns.
Frequency: 10-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Hepatic encephalopathy management
Standard therapies for hepatic encephalopathy including non-absorbable disaccharides and targeted antibiotics to reduce ammonia and normalize glutamine.
Protein intake optimization
Careful balancing of protein intake to maintain nutrition while minimizing ammonia production from protein metabolism.
Additional treatment options
Ammonia level surveillance
Regular blood and CSF ammonia monitoring to assess treatment response and guide therapy adjustments.
monitoringSleep positioning and head elevation
Elevated head of bed positioning to reduce intracranial pressure fluctuations associated with elevated CSF glutamine.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Csf Glutamine Concentration C5139581?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JB, Johnson KL, Williams RM. Consensus guidelines for cerebrospinal fluid amino acid analysis in metabolic disorders. J Inherit Metab Dis. 2022.
Chen PY, Patel N, Garcia-Rodriguez AA. Cerebrospinal fluid glutamine concentration abnormalities: Mechanisms and clinical significance. Neurochem Res. 2020.
Thompson HC, Lee SY, Anderson MR, Kim SJ. Evaluation of CSF glutamine levels as biomarkers in hepatic encephalopathy: A prospective cohort study. Hepatology. 2019.
Brown DW, Martinez VM, Whitehouse AC. Metabolic disturbances in cerebrospinal fluid glutamine: A systematic review and meta-analysis. Metab Brain Dis. 2023.
Medication Comparisons
Compare medications used to treat Abnormal Csf Glutamine Concentration C5139581. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy