Abnormal Csf Histidine Concentration C5139620
Abnormal CSF histidine concentration refers to atypical levels of this amino acid in the fluid around the brain and spine. It may be linked to metabolic or neurological disorders and is found through lab testing. Treatment focuses on addressing the underlying condition affecting histidine metabolism.
Key facts at a glance
- ICD-10
- G31.82
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Intellectual disability
(neurologic)Speech delay
(neurologic)Eczema
(neurologic)Seizures
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Neurotransmitter precursor tracking
Monitoring histidine levels as a histamine precursor helps assess whether the imbalance affects neurotransmitter function. Includes evaluation of related metabolites.
Histidine-tailored meal planning
Individualized dietary guidance to maintain optimal histidine intake, neither excessive nor deficient. Emphasizes varied protein sources to avoid amino acid imbalances.
Additional treatment options
Allergen and histamine trigger management
Lifestyle modifications to minimize histamine release when histidine metabolism is a concern. Includes identifying and avoiding personal histamine triggers.
lifestyleQuercetin and flavonoid support
Natural flavonoids like quercetin may support histamine metabolism. Food-based approaches preferred over high-dose supplementation.
complementaryHistidine-rich food guidance
Education about excellent histidine food sources including poultry, fish, beef, pork, and certain dairy products. Helps families incorporate appropriate sources.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Csf Histidine Concentration C5139620?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JC, Johnson AB, Williams KL. Neurochemical alterations in amino acid metabolism: Focus on histidine transport across the blood-brain barrier. Metab Brain Dis. 2019.
Brown LM, Davis RP, Garcia ER, Anderson NH. American Academy of Neurology Consensus Guidelines: Cerebrospinal Fluid Biomarkers in Metabolic Disorders. Neurology. 2021.
Martinez FR, Thompson SH, Lee KW. Randomized Controlled Trial of Dietary Intervention in Patients with Abnormal CSF Amino Acid Profiles. J Clin Invest. 2018.
Wilson PJ, Chen Y, Taylor MA. Systematic Review and Meta-Analysis of CSF Histidine Levels in Neurological and Metabolic Diseases. Clin Chem. 2022.
Medication Comparisons
Compare medications used to treat Abnormal Csf Histidine Concentration C5139620. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy