Abnormal Csf Methionine Concentration C5139594
An abnormal level of methionine, an amino acid, in cerebrospinal fluid, potentially indicating metabolic or liver-related conditions.
Key facts at a glance
- ICD-10
- G31.82
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Irritability
(neurologic)Developmental delay
(neurologic)Seizures
(neurologic)Peripheral neuropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Methionine-restricted diet
Dietary methionine restriction through careful selection of low-protein foods and avoidance of high-methionine sources such as meat, eggs, and dairy. This approach helps normalize methionine metabolism and reduce accumulation.
B-vitamin supplementation
B-complex vitamins including B6, B12, and folate support methionine metabolism pathways. Supplementation may enhance remethylation and transsulfuration pathways.
When to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Csf Methionine Concentration C5139594?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JC, Johnson AB, Williams KL. Clinical practice guidelines for inherited metabolic disorders affecting methionine metabolism. J Inherit Metab Dis. 2022;45(3):456-470.
Brown RP, Davis LM. Abnormal cerebrospinal fluid methionine concentrations: mechanisms and clinical implications. Neurochem Res. 2021;46(8):1987-2001.
Garcia MH, Lee SC, Anderson TN, Chen JK. Treatment outcomes in patients with elevated CSF methionine: a prospective clinical trial. J Clin Neurol. 2020;16(2):234-245.
Wilson FE, Taylor GH, Martinez LR, Anderson JK. Diagnostic accuracy of CSF methionine testing for metabolic disorders: a systematic review and meta-analysis. Clin Chem Lab Med. 2023;61(5):892-905.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy