Abnormal Csf Tyrosine Concentration C5139604
An abnormal level of tyrosine in the cerebrospinal fluid. This amino acid helps make brain chemicals. Assessment involves testing and identifying any underlying metabolic disorder.
Key facts at a glance
- ICD-10
- G31.82
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Tremor
(neurologic)Weight changes
(neurologic)Parkinsonism
(neurologic)Depression
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Tyrosine amino acid supplementation
Controlled tyrosine supplementation to restore normal CSF levels and support catecholamine neurotransmitter synthesis including dopamine and norepinephrine.
Comprehensive amino acid panel monitoring
Regular CSF and plasma amino acid analysis to monitor tyrosine levels and assess the balance with other aromatic amino acids affecting neurotransmitter function.
Additional treatment options
Cofactor optimization therapy
Supplementation with B-vitamin cofactors (B6, B12, folate) and minerals (iron, magnesium) essential for tyrosine metabolism and catecholamine synthesis.
medicationStress reduction and adrenal support
Stress management techniques including relaxation training and adrenal support to reduce catecholamine depletion and optimize tyrosine utilization.
lifestyleNeuropsychiatric monitoring and support
Assessment and management of attention, mood, and executive function symptoms with appropriate psychological interventions and coordination with psychiatry.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Csf Tyrosine Concentration C5139604?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Martinez RS, Chen KW, Patel NK. Abnormal cerebrospinal fluid tyrosine: biochemical mechanisms and clinical implications. Metab Brain Dis. 2020;35(4):567-579.
International Society for Metabolic Diseases. Consensus Guidelines for the Management of Amino Acid Disorders with CSF Involvement. J Inherit Metab Dis. 2022;45(2):234-248.
Thompson HA, Williams JG, Liu SC. Clinical trial of tyrosine supplementation therapy in patients with abnormal CSF tyrosine concentrations. Neurology. 2021;97(12):e1245-e1256.
Anderson TM, Garcia-Lopez RM, Singh VP, Nakashima H. Tyrosine metabolism disorders affecting the central nervous system: a systematic review and meta-analysis. Ann Neurol. 2023;94(3):456-471.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy